ArticleThe Journal of physiology1996
Synchronous release of ATP and neurotransmitter within milliseconds of a motor nerve impulse in the frog.
Article in The Journal of physiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
29 citing papers in PubMed, 123 citations in OpenAlex.
- Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance.Nature communications · 2025Article
- Presynaptic Purinergic Modulation of the Rat Neuro-Muscular Transmission.Current issues in molecular biology · 2023Article
- Astrocyte regulation of synaptic signaling in psychiatric disorders.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2023Review
- Mechanical Disturbance of Osteoclasts Induces ATP Release That Leads to Protein Synthesis in Skeletal Muscle through an Akt-mTOR Signaling Pathway.International journal of molecular sciences · 2022Article
- Purines released from astrocytes inhibit excitatory synaptic transmission in the ventral horn of the spinal cord.Frontiers in neural circuits · 2014Article
- Neuronal involvement in muscular atrophy.Frontiers in cellular neuroscience · 2014Review
- Purinergic signalling in the musculoskeletal system.Purinergic signalling · 2013Review
- Evidence for constitutively-active adenosine receptors at mammalian motor nerve endings.European journal of pharmacology · 2012Article
- Signaling processes for initiating smooth muscle contraction upon neural stimulation.The Journal of biological chemistry · 2009Article
- Selective disruption of the mammalian secretory apparatus enhances or eliminates calcium current modulation in nerve endings.Proceedings of the National Academy of Sciences of the United States of America · 2008Article
- International Union of Pharmacology LVIII: update on the P2Y G protein-coupled nucleotide receptors: from molecular mechanisms and pathophysiology to therapy.Pharmacological reviews · 2006Review
- Elementary purinergic Ca2+ transients evoked by nerve stimulation in rat urinary bladder smooth muscle.The Journal of physiology · 2005Article
- Quantal release of ATP from clusters of PC12 cells.The Journal of physiology · 2004Article
- Phorbol esters and adenosine affect the readily releasable neurotransmitter pool by different mechanisms at amphibian motor nerve endings.The Journal of physiology · 2003Article
- ATP acts via P2Y1 receptors to stimulate acetylcholinesterase and acetylcholine receptor expression: transduction and transcription control.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Ecto-AMP deaminase blunts the ATP-derived adenosine A2A receptor facilitation of acetylcholine release at rat motor nerve endings.The Journal of physiology · 2003Article
- Modulatory role of adenosine receptors in insect motor nerve terminals.Neurochemical research · 2003Article
- Release of ATP induced by hypertonic solutions in Xenopus oocytes.The Journal of physiology · 2003Article
- Regulation by Rab3A of an endogenous modulator of neurotransmitter release at mouse motor nerve endings.The Journal of physiology · 2002Article
- ATP regulates the differentiation of mammalian skeletal muscle by activation of a P2X5 receptor on satellite cells.The Journal of cell biology · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
1. It has been suggested that ATP is released together with the neurotransmitter acetylcholine (ACh) and, after hydrolysis to adenosine, is the primary physiological mediator of prejunctional neuromuscular depression. To evaluate whether ATP is released with sufficient rapidity to mediate prejunctional depression, outside-out patches containing both ATP-gated and ACh-gated ion channels were made from acutely dissociated guinea-pig sympathetic neurons and used to detect the co-release of nucleotide and neurotransmitter in frog cutaneous pectoris nerve-muscle preparations. 2. In a normal bathing solution in which muscle nicotinic receptors were blocked, a single stimulus to the motor nerve produced channel openings in the detector patch characteristic of both ATP and ACh. 3. In the remaining experiments, preparations were treated with sufficient hexamethonium (200 microM) to block nicotinic responses in the detector patch. In these experiments, a single temporally isolated nerve impulse caused the synchronous opening of ATP-gated channels in the detector patch with a latency of < 5 ms when patches were placed within 10 microns of the motor nerve ending. This multichannel phasic response was followed by trail of discrete channel openings characteristic of ATP-gated channels. 4. The selective ATP antagonist suramin (50 microM) reversibly eliminated the response to nerve stimulation. 5. The results suggest that ATP is released synchronously together with the neurotransmitter ACh in response to an individual nerve impulse and with a brief latency characteristic of quantal release from synaptic vesicles.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.