ArticleJournal of clinical immunology1996
Long-term follow-up of health in blood donors with primary selective IgA deficiency.
Article in Journal of clinical immunology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
What it found
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Who cites it
26 citing papers in PubMed, 100 citations in OpenAlex.
- Immunoglobulin A controls intestinal virus colonization to preserve immune homeostasis.Cell host & microbe · 2025Article
- Clinical manifestation for immunoglobulin A deficiency: a systematic review and meta-analysis.Allergy, asthma, and clinical immunology : official journal of the Canadian Society of Allergy and Clinical Immunology · 2023Review
- The role of B cells in cancer development.Frontiers in oncology · 2022Review
- Therapeutic immunoglobulin A antibody for dysbiosis-related diseases.International immunology · 2021Review
- Diversity and dynamism of IgA-microbiota interactions.Nature reviews. Immunology · 2021Review
- A novel method to standardise serum IgA measurements shows an increased prevalence of IgA deficiency in young children with recurrent respiratory tract infections.Clinical & translational immunology · 2021Article
- Primary Humoral Immune Deficiencies: Overlooked Mimickers of Chronic Immune-Mediated Gastrointestinal Diseases in Adults.International journal of molecular sciences · 2020Review
- The Epidemiology and Clinical Manifestations of Autoimmunity in Selective IgA Deficiency.Clinical reviews in allergy & immunology · 2020Review
- MZB1 promotes the secretion of J-chain-containing dimeric IgA and is critical for the suppression of gut inflammation.Proceedings of the National Academy of Sciences of the United States of America · 2019Article
- Follow-up and outcome of symptomatic partial or absolute IgA deficiency in children.European journal of pediatrics · 2019Article
- Population-Based Screening for Selective Immunoglobulin A (IgA) Deficiency in Lithuanian Children Using a Rapid Antibody-Based Fingertip Test.Medical science monitor : international medical journal of experimental and clinical research · 2016Article
- Risk of Infections Among 2100 Individuals with IgA Deficiency: a Nationwide Cohort Study.Journal of clinical immunology · 2016Article
- Reversal of Immunoglobulin A Deficiency in Children.Journal of clinical immunology · 2015Article
- IgA deficiency, autoimmunity & pregnancy: a population-based matched cohort study.Journal of clinical immunology · 2014Article
- Skin manifestations of primary immune deficiency.Clinical reviews in allergy & immunology · 2014Review
- IgA deficiency and mortality: a population-based cohort study.Journal of clinical immunology · 2013Observational
- Autoimmune atrophic gastritis--pathogenesis, pathology and management.Nature reviews. Gastroenterology & hepatology · 2013Review
- Clinical symptoms in adults with selective IgA deficiency: a case-control study.Journal of clinical immunology · 2013Article
- Selective IgA deficiency: clinical and laboratory features of 118 children in Turkey.Journal of clinical immunology · 2012Article
- Selective IgA deficiency in children in Israel.Journal of clinical immunology · 2010Article
Corrections and comments
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Authors and funding
1 author at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A 20-year health follow-up study of 159 initially healthy blood donors with a severe deficiency of serum IgA ( < 0.05 x 10(-3) g/L) and of 45 donors with decreased serum IgA (0.05 x 10(-3)-0.8 g/L) was carried out. The findings indicate that persons with a severe deficiency of and decreased serum IgA who are healthy as young adults have an increased susceptibility to pneumonia and recurrent episodes of other respiratory infections and a higher risk of developing autoimmune diseases in middle age. Vitiligo, autoimmune hypothyreosis, milk intolerance, and possible rheumatoid arthritis were associated with severe IgA deficiency, but otherwise different degrees of IgA deficiency seem to be similar with respect to the appearance of diseases. Regardless of the fact that a total of 163 (80%) of the 204 IgA-deficient subjects had-episodes of infections, drug allergy, or autoimmune or atopic disease, the finding of primary, selective IgA deficiency in a healthy adult per se does not seem to predict severe life-threatening illnesses at least during 20 years of life.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.