ArticleScandinavian journal of gastroenterology1996
Plasma interleukin-6 levels in patients with cirrhosis. Relationship to endotoxemia, tumor necrosis factor-alpha, and hyperdynamic circulation.
Article in Scandinavian journal of gastroenterology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
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Who cites it
23 citing papers in PubMed, 104 citations in OpenAlex.
- Hyaluronic acid levels predict increased risk of non-AIDS death in hepatitis-coinfected persons interrupting antiretroviral therapy in the SMART Study.Antiviral therapy · 2011Trial
- A novel sweat sensor detects inflammatory differential rhythmicity patterns in inpatients and outpatients with cirrhosis.NPJ digital medicine · 2024Article
- Frailty in end-stage liver disease: Understanding pathophysiology, tools for assessment, and strategies for management.World journal of gastroenterology · 2023Review
- Sex Drives Functional Changes in the Progression and Regression of Liver Fibrosis.International journal of molecular sciences · 2023Article
- Identification and Analysis of Gut Microbiota and Functional Metabolism in Decompensated Cirrhosis with Infection.Journal of clinical and translational hepatology · 2023Article
- Analysis of related factors of portal vein thrombosis in liver cirrhosis.BMC gastroenterology · 2023Article
- Exaggerated inflammatory response to bacterial products in decompensated cirrhotic patients is orchestrated by interferons IL-6 and IL-8.American journal of physiology. Gastrointestinal and liver physiology · 2022Article
- Common musculoskeletal disorders in chronic liver disease patients.Joint diseases and related surgery · 2021Article
- Management of bacterial infection in the liver transplant candidate.World journal of hepatology · 2018Review
- Pathophysiologic Implications of Cytokines Secretion during Liver Transplantation Surgery.International journal of medical sciences · 2018Review
- Risk factors for hospitalizations among patients with cirrhosis: A prospective cohort study.PloS one · 2017Article
- Cirrhosis is a risk factor for total hip arthroplasty for avascular necrosis.Acta orthopaedica · 2016Article
- Gut-liver axis in liver cirrhosis: How to manage leaky gut and endotoxemia.World journal of hepatology · 2015Review
- Liver Failure Impairs the Intrahepatic Elimination of Interleukin-6, Tumor Necrosis Factor-Alpha, Hepatocyte Growth Factor, and Transforming Growth Factor-Beta.BioMed research international · 2015Article
- Risk factors and outcome of bacterial infections in cirrhosis.World journal of gastroenterology · 2014Review
- Circulating endotoxin and interleukin-6 levels are associated with Doppler-evaluated pulmonary vascular resistance in cirrhotic patients.Hepatology international · 2012Article
- Estrogen suppresses heptatic IκB expression during short-term alcohol exposure.Inflammation research : official journal of the European Histamine Research Society ... [et al.] · 2012Article
- Intestinal and plasma VEGF levels in cirrhosis: the role of portal pressure.Journal of cellular and molecular medicine · 2012Article
- Increased intestinal macromolecular permeability and urine nitrite excretion associated with liver cirrhosis with ascites.World journal of gastroenterology · 2008Article
- Liver regeneration is suppressed in alcoholic cirrhosis: correlation with decreased STAT3 activation.Alcohol (Fayetteville, N.Y.) · 2007Article
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Authors and funding
10 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundLiver cirrhosis with portal hypertension is associated with hyperdynamic circulation characterized by generalized vasodilatation and increased cardiac output and regional blood flows. Patients with liver cirrhosis present with increased levels of interleukin-6 (IL-6), which may inhibit vascular smooth-muscle contraction. We investigated whether increased plasma IL-6 levels contribute to the pathogenesis of hyperdynamic circulation observed in cirrhotic patients and whether they are correlated with plasma tumor necrosis factor-alpha (TNF-alpha) and endotoxin concentrations.
methodsIn 58 consecutive cirrhotic patients and 34 healthy subjects the plasma concentrations of TNF-alpha and IL-6 were measured with enzyme-linked immunosorbent assay, and endotoxin determinations with a limulus assay. In addition, 52 cirrhotic patients underwent a hemodynamic study using Swan-Ganz catheterization.
resultsPlasma TNF-alpha, IL-6, and endotoxin levels were significantly higher in cirrhotic patients than in healthy subjects (7.3 +/- 0.2 versus 5.8 +/- 0.1 pg/ml, 6.4 +/ 0.8 versus 2.0 +/- 0.2 pg/ml, and 7.6 +/- 1.2 versus 2.8 +/- 0.3 pg/ml, respectively; p < 0.01). In cirrhotic patients the plasma levels of TNF-alpha IL-6, and endotoxin progressively increased in relation to the severity of liver dysfunction (graded by Pugh's classification). A significant correlation was observed between plasma TNF-alpha and IL-6 levels (r = 0.48, p < 0.001), whereas no correlation was observed between plasma endotoxin levels and plasma TNF-alpha and IL-6 levels. Plasma IL-6 levels correlated negatively with systemic vascular resistance in patients with cirrhosis (r = 0.5, p < 0.01).
conclusionsPlasma IL-6 levels are increased in patients with cirrhosis. The severity of liver cirrhosis is an important factor for the occurrence of increased IL-6 levels. IL-6 may play a role in the hyperdynamic circulation observed in patients with cirrhosis.
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