ArticleBritish journal of pharmacology1996
Two types of ATP-sensitive potassium channels in rat portal vein smooth muscle cells.
Article in British journal of pharmacology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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Who cites it
29 citing papers in PubMed, 104 citations in OpenAlex.
- Intracellular Calcium Changes Correlate with Mitochondrial Dynamics After Differential Modulation of KATP Channels in a Cellular Model of Parkinson's Disease.Neurochemical research · 2025Article
- Kir6.1 and SUR2B in Cantú syndrome.American journal of physiology. Cell physiology · 2022Review
- The Ion Channel and GPCR Toolkit of Brain Capillary Pericytes.Frontiers in cellular neuroscience · 2020Review
- The role of KActa pharmacologica Sinica · 2018Review
- Risk factors and global cognitive status related to brain arteriolosclerosis in elderly individuals.Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2017Article
- Adenosine Triphosphate-Sensitive Potassium Currents in Heart Disease and Cardioprotection.Cardiac electrophysiology clinics · 2016Review
- The shifting landscape of KATP channelopathies and the need for 'sharper' therapeutics.Future medicinal chemistry · 2016Review
- ATP Sensitive Potassium Channels in the Skeletal Muscle Function: Involvement of the KCNJ11(Kir6.2) Gene in the Determination of Mechanical Warner Bratzer Shear Force.Frontiers in physiology · 2016Review
- Electrophysiologic consequences of KATP gain of function in the heart: Conduction abnormalities in Cantu syndrome.Heart rhythm · 2015Article
- Molecular analysis of ATP-sensitive K⁺ channel subunits expressed in mouse vas deferens myocytes.British journal of pharmacology · 2014Article
- Hypotension due to Kir6.1 gain-of-function in vascular smooth muscle.Journal of the American Heart Association · 2013Article
- KATP channels and cardiovascular disease: suddenly a syndrome.Circulation research · 2013Review
- Regulation of the ATP-sensitive potassium channel subunit, Kir6.2, by a Ca2+-dependent protein kinase C.The Journal of biological chemistry · 2012Article
- Interaction with caveolin-1 modulates vascular ATP-sensitive potassium (KATP) channel activity.The Journal of physiology · 2010Article
- Silencing vascular smooth muscle ATP-sensitive K+ channels with caveolin-1.The Journal of physiology · 2010Review
- Muscle KATP channels: recent insights to energy sensing and myoprotection.Physiological reviews · 2010Review
- Review
- PKA-dependent activation of the vascular smooth muscle isoform of KATP channels by vasoactive intestinal polypeptide and its effect on relaxation of the mesenteric resistance artery.Biochimica et biophysica acta · 2008Article
- PKA phosphorylation of SUR2B subunit underscores vascular KATP channel activation by beta-adrenergic receptors.American journal of physiology. Regulatory, integrative and comparative physiology · 2007Article
- Physiological roles of ATP-sensitive K+ channels in smooth muscle.The Journal of physiology · 2006Review
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. Single-channel recordings were made from single, enzymatically isolated smooth muscle cells of rat portal vein by the patch-clamp technique. 2. Unitary potassium currents were identified through two types of K-channels with conductances in 60:130 mM K-gradient of 50 and 22 pS; these are referred to as LK and MK channels respectively. 3. The LK channels became extremely active if isolated patches were created into nucleotide-free solution; activity was inhibited by ATP applied to the inner surface of the patch with a half maximal inhibition (Ki) of 11-23 microM. Channel activity declined and disappeared with time and could be regenerated by a brief application of Mg-ATP or a nucleoside diphosphate such as UDP (in the presence of Mg). LK channel activity was rarely stimulated by levcromakalim and not by pinacidil (K-channel openers, KCOs) but was blocked by glibenclamide. 4. Activity of MK channels declined if isolated patches were created into nucleotide free solution; activity reappeared if UDP or ATP alone (in the presence of Mg) was applied; pinacidil or levcromakalim in the presence of ATP or UDP further increased channel activity which was blocked by glibenclamide. 5. The LK channel inhibited by ATPi is very similar in its conductance and other properties to the KATP channel described in tissues other than smooth muscle, in its conductance and properties the MK channel resembles the KNDP channel we have previous described as present in other smooth muscles and opening in responses to KCOs.
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