ArticleBritish journal of pharmacology1996
Full sensitivity of P2X2 purinoceptor to ATP revealed by changing extracellular pH.
Article in British journal of pharmacology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 49 papers.
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Who cites it
49 citing papers in PubMed, 135 citations in OpenAlex.
- Purinergic signaling in the peripheral vestibular system.Purinergic signalling · 2022Review
- Distinct purinergic signaling pathways in prepubescent mouse spermatogonia.The Journal of general physiology · 2016Article
- Regulation of ATP-gated P2X channels: from redox signaling to interactions with other proteins.Antioxidants & redox signaling · 2014Review
- Ion channels and migraine.Headache · 2014Review
- Acid-base transport in pancreas-new challenges.Frontiers in physiology · 2013Review
- Heteromeric assembly of P2X subunits.Frontiers in cellular neuroscience · 2013Review
- Functional identification of close proximity amino acid side chains within the transmembrane-spanning helixes of the P2X2 receptor.PloS one · 2013Article
- Article
- The role of purinergic receptors in cancer-induced bone pain.Journal of osteoporosis · 2012Article
- Activation and regulation of purinergic P2X receptor channels.Pharmacological reviews · 2011Review
- Allosteric modulation of purine and pyrimidine receptors.Advances in pharmacology (San Diego, Calif.) · 2011Review
- Mouse Leydig cells express multiple P2X receptor subunits.Purinergic signalling · 2009Article
- Orthosteric and allosteric binding sites of P2X receptors.European biophysics journal : EBJ · 2009Review
- Identification of the amino acid residues in the extracellular domain of rat P2X(7) receptor involved in functional inhibition by acidic pH.British journal of pharmacology · 2009Article
- Purines, the carotid body and respiration.Respiratory physiology & neurobiology · 2007Review
- P2Y1 receptor modulation of the pre-Bötzinger complex inspiratory rhythm generating network in vitro.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2007Article
- Excitatory effect of ATP on rat area postrema neurons.Purinergic signalling · 2006Article
- Pharmacology of P2X channels.Pflugers Archiv : European journal of physiology · 2006Review
- Jejunal afferent nerve sensitivity in wild-type and TRPV1 knockout mice.The Journal of physiology · 2004Article
- Identification of ectodomain regions contributing to gating, deactivation, and resensitization of purinergic P2X receptors.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2004Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A full pharmacological characterization was carried out on a recombinant ATP-gated ion channel (P2X2 purinoceptor) expressed in Xenopus oocytes. This slowly-desensitizing neuronal P2X2 purinoceptor, activated by ATP (EC50 = 4.6 +/- 1 microM at pH 7.4; n = 4), showed the agonist potency order: ATP > or = 2-MeSATP = ATP gamma S > or = ATP alpha S > > Bz-ATP. The receptor affinity for ATP was enhanced 5-10 fold by acidifying the bathing solution (to pH 6.5) but was diminished 4-5 fold in an alkaline solution (pH 8.0). The maximum activity of P2X2 purinoceptors and the activity order of a series of nucleotides were unaltered by changing extracellular pH. Interestingly, ATP sensitivity at a recombinant P2Y1 purinoceptor remained unaltered with changing extracellular pH. These results indicate that acidotic conditions in the synaptic cleft could strengthen purinergic transmission at neuronal P2X2 purinoceptors.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.