ArticleJournal of medical genetics1996
A modifying locus for familial adenomatous polyposis may be present on chromosome 1p35-p36.
Article in Journal of medical genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
14 citing papers in PubMed, 66 citations in OpenAlex.
- Molecular analysis of the APC and MUTYH genes in Galician and Catalonian FAP families: a different spectrum of mutations?BMC medical genetics · 2009Article
- Familial adenomatous polyposis: experience from a study of 1164 unrelated german polyposis patients.Hereditary cancer in clinical practice · 2005Article
- Foxl1 is a mesenchymal Modifier of Min in carcinogenesis of stomach and colon.Genes & development · 2005Article
- Article
- Mutation cluster region, association between germline and somatic mutations and genotype-phenotype correlation in upper gastrointestinal familial adenomatous polyposis.The American journal of pathology · 2002Article
- COX-2 and cancer: a new approach to an old problem.British journal of pharmacology · 2001Review
- Article
- Gastroduodenal lesions in familial adenomatous polyposis.Surgery today · 2000Review
- Tumor burden and clonality in multiple intestinal neoplasia mouse/normal mouse aggregation chimeras.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- New developments in phospholipase A2.Lipids · 1999Review
- The intestinal epithelium and its neoplasms: genetic, cellular and tissue interactions.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1998Review
- Genotype-phenotype correlations in attenuated adenomatous polyposis coli.American journal of human genetics · 1998Article
- Article
- Dietary fat influences on polyp phenotype in multiple intestinal neoplasia mice.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
Corrections and comments
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Authors and funding
7 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Mutations of the APC gene cause familial adenomatous polyposis (FAP) in humans and multiple intestinal neoplasia (Min) in laboratory mouse strains. A dominant modifying gene (Mom1), which partially suppresses the min phenotype, has been mapped to mouse chromosome 4. This region is syntenic with human chromosome 1p35-p36. The phospholipase A2 (Pla2s) locus is an excellent candidate for Mom1 and the equivalent human locus PLA2G2A is found on chromosome 1p35. It does not necessarily follow, however, than any modifier of mouse polyposis also influences human disease. In order to test whether a locus on 1p modifies FAP, subjects from 28 FAP families have been typed at microsatellite loci on this chromosome arm. The severity of their duodenal polyposis has also been assessed by endoscopy. Pedigree (lod score) linkage analysis found no evidence of a simple, dominant modifying gene, comparable with the action of Mom1 in inbred mouse strains. Given the more complex genetic and environmental interactions likely to exist in outbred human populations, it is probably more appropriate to use tests which do not specify a mode of inheritance. Using these methods of analysis, the data suggest that a locus on chromosome 1p35-p36 may influence the severity of duodenal FAP.
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