ArticleJournal of clinical microbiology1996
Studies of in vivo distribution of bovine herpesvirus type 4 in the natural host.
Article in Journal of clinical microbiology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 81 citations in OpenAlex.
- Re-evaluation of bovine herpesvirus 4 genotyping based on the thymidine kinase gene.Journal of virology · 2026Article
- Review
- First detection and impact of bovine herpesvirus type 4 on dairy cattle reproduction in Thailand.Veterinary world · 2024Article
- Epidemiological survey of bovine gammaherpesvirus 4 (BoHV-4) infection in cattle and buffalo from Pakistan.Veterinary research communications · 2023Article
- Article
- Bovine Herpesvirus-4-Vectored Delivery of Nipah Virus Glycoproteins Enhances T Cell Immunogenicity in Pigs.Vaccines · 2020Article
- An assessment of bovine herpes virus 4 as a causative agent in abortions and neonatal death.The Onderstepoort journal of veterinary research · 2020Article
- Article
- Bovine herpes virus type-4 infection among postpartum dairy cows in California: risk factors and phylogenetic analysis.Epidemiology and infection · 2018Article
- Bovine herpesvirus 4 DNA is not detected in free-ranging domestic cats from California, Colorado or Florida.Journal of feline medicine and surgery · 2017Article
- The role of herpesviruses (BoHV-1 and BoHV-4) and pestiviruses (BVDV and BDV) in ruminant abortion cases in western Turkey.Tropical animal health and production · 2016Article
- Molecular Analysis of South African Ovine Herpesvirus 2 Strains Based on Selected Glycoprotein and Tegument Genes.PloS one · 2016Article
- Article
- Search for the genome of bovine herpesvirus types 1, 4 and 5 in bovine semen.Open veterinary journal · 2013Article
- Detection of bovine herpesvirus 4 DNA in aborted bovine fetuses.Canadian journal of veterinary research = Revue canadienne de recherche veterinaire · 2007Article
- VirOligo: a database of virus-specific oligonucleotides.Nucleic acids research · 2002Article
- Detection of bovine herpesvirus 4 (BoHV-4) DNA in the cell fraction of milk of dairy cattle with history of BoHV-4 infection.Journal of clinical microbiology · 2000Article
- Replication of bovine herpesvirus type 4 in human cells in vitro.Journal of clinical microbiology · 1998Article
- Bovine herpesvirus 4 BORFE2 protein inhibits Fas- and tumor necrosis factor receptor 1-induced apoptosis and contains death effector domains shared with other gamma-2 herpesviruses.Journal of virology · 1997Article
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The in vivo distribution of bovine herpesvirus type 4 (BHV-4) was examined by testing nasal and conjunctival exudates, peripheral blood leukocytes, and various organs of experimentally infected calves. For virus detection, a nested PCR assay, virus isolation, and immunohistochemistry were applied. The nervous system and the muscles were free of viral DNA. Liver and intestinal lymph nodes contained low amounts of virus (less than two copies per 1 microgram of cellular DNA). Intestinal, tonsil, thymus, and kidney tissues contained more viral DNA copies (5 to 50 copies per 1 microgram of cellular DNA). The highest amounts of BHV-4 DNA (50 to 500 copies per 1 microgram of cellular DNA) were found in the spleen, lungs, trachea, and nasal epithelium. Amplification of DNA from blood lymphocytes through postinoculation (p.i.) day 48 proved that the virus started to replicate in these cells immediately after inoculation of the calves and that intensive virus growth took place during the 7 to 8 weeks of the infection. The number of virus-infected lymphocytes reached the maximum on p.i. days 22 to 26 and slowly declined thereafter. Virus-infected cells were found only in the spleen on p.i. day 48 by immunohistochemistry. Western blotting (immunoblotting) detected signs of an immune response against 9 of the 29 BHV-4 proteins.
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