ArticleAntimicrobial agents and chemotherapy1996
Reporter gene technology to assess activity of antimycobacterial agents in macrophages.
Article in Antimicrobial agents and chemotherapy, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
21 citing papers in PubMed, 41 citations in OpenAlex.
- Quantification of Mycobacterium tuberculosis Growth in Cell-Based Infection Assays by Time-Lapse Fluorescence Microscopy.Methods in molecular biology (Clifton, N.J.) · 2024Article
- In-vivo monitoring of infectious diseases in living animals using bioluminescence imaging.Virulence · 2018Review
- Rapid measurement of antituberculosis drug activity in vitro and in macrophages using bioluminescence.The Journal of antimicrobial chemotherapy · 2012Article
- Synergistic drug combinations for tuberculosis therapy identified by a novel high-throughput screen.Antimicrobial agents and chemotherapy · 2011Article
- Rapid assessment of antibacterial activity against Mycobacterium ulcerans by using recombinant luminescent strains.Antimicrobial agents and chemotherapy · 2010Article
- Article
- Antimycobacterial susceptibility testing methods for natural products research.Brazilian journal of microbiology : [publication of the Brazilian Society for Microbiology] · 2010Article
- Assessment of in vitro immunity to Mycobacterium tuberculosis in a human peripheral blood infection model using a luciferase reporter construct of M. tuberculosis H37Rv.Clinical and experimental immunology · 2006Article
- Alternative luciferase for monitoring bacterial cells under adverse conditions.Applied and environmental microbiology · 2005Article
- Improved green fluorescent protein reporter gene-based microplate screening for antituberculosis compounds by utilizing an acetamidase promoter.Antimicrobial agents and chemotherapy · 2003Article
- Simple fibroblast-based assay for screening of new antimicrobial drugs against Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 2002Article
- Use of aminoglycosides in treatment of infections due to intracellular bacteria.Antimicrobial agents and chemotherapy · 2001Review
- Use of a recombinant strain of Mycobacterium avium expressing beta-galactosidase to evaluate the activities of antimycobacterial agents inside macrophages.Antimicrobial agents and chemotherapy · 2001Article
- The stringent response of Mycobacterium tuberculosis is required for long-term survival.Journal of bacteriology · 2000Article
- How novel methods can help discover more information about foodborne pathogens.The Canadian journal of infectious diseases = Journal canadien des maladies infectieuses · 2000Article
- Assessment of immunity to mycobacterial infection with luciferase reporter constructs.Infection and immunity · 1999Article
- Development of a firefly luciferase-based assay for determining antimicrobial susceptibility of Mycobacterium avium subsp. paratuberculosis.Journal of clinical microbiology · 1999Article
- Bactericidal activities of the pyrrole derivative BM212 against multidrug-resistant and intramacrophagic Mycobacterium tuberculosis strains.Antimicrobial agents and chemotherapy · 1998Article
- Green fluorescent protein reporter microplate assay for high-throughput screening of compounds against Mycobacterium tuberculosis.Antimicrobial agents and chemotherapy · 1998Article
- Bioluminescence screening in vitro (Bio-Siv) assays for high-volume antimycobacterial drug discovery.Antimicrobial agents and chemotherapy · 1996Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Reporter strains of Mycobacterium tuberculosis and Mycobacterium bovis BCG endogenously expressing firefly luciferase were used in bioluminescence assays to evaluate the activities of isoniazid and rifampin against mycobacteria sequestered in human macrophages. This methodology allowed the efficacy of antibiotics against intracellular mycobacteria to be assessed without the labor-intensive procedures and protracted incubation requirements associated with conventional CFU determinations.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.