A new voyage of discovery: transport through the hepatocyte.

J L Gollan, S D Zucker

Open access · greenAbstract readReview

In one paragraph

Review in Transactions of the American Clinical and Climatological Association, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it

0cells of the map it votes in

1citing papers in PubMed

–field-weighted citation impact, top 100% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 6 citations in OpenAlex.

First Human Biomonitoring Evidence of Strobilurin Fungicide Exposure in South China: Impact on Oxidative Stress and Liver Damage.Toxics · 2025
Article

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors at 1 institution in 1 country.

J L GollanDepartment of Medicine, Brigham and Women's Hospital, Boston, Massachusetts 02115, USA.

S D Zucker

Brigham and Women's Hospital · US

Funding

MECHANISMS OF WATER FLOW ACROSS BIOLOGICAL MEMBRANESR01DK043955 · NIDDK · UNIVERSITY OF PITTSBURGH AT PITTSBURGH · PI ZEIDEL, MARK L. · 1991 to 2009

$3.2M

HEPATOCELLULAR TRANSPORT OF SMALL HYDROPHOBIC COMPOUNDSK11DK002047 · NIDDK · BRIGHAM AND WOMEN'S HOSPITAL · PI ZUCKER, STEPHEN D · 1991 to 1995

–

HEPATIC PATHWAYS OF HEME AND BILIRUBIN METABOLISMR01DK036887 · NIDDK · UNIVERSITY OF ADELAIDE · PI GOLLAN, JOHN L. · 1986 to 1999

–

NIDDK NIH HHS DK-02047NIDDK NIH HHS DK-36887NIDDK NIH HHS DK-43955

6 · The paper itself

Abstract

In summary, hepatocellular membranes likely play an essential role in the binding and directed trafficking of unconjugated bilirubin, and potentially of a variety of other small hydrophobic molecules. Targeting of these substrates to the endoplasmic reticulum is determined by membrane cholesterol content, surface area and integral protein binding and enzyme activity. The rate of intracellular transport potentially may be modulated by the concentration of cytosolic binding proteins, but, at least for ligandin, this protein does not appear to function primarily as an intracellular bilirubin transporter.

Indexed as

AnimalsBilirubinBiological Transport, ActiveGlutathione TransferaseHumansIn Vitro TechniquesLiverMicroscopy, ElectronModels, BiologicalSubcellular FractionsBilirubinGlutathione Transferase

Identifiers

PMID8725559

PMCPMC2376562

OpenAlexW51192904

What OpenQuestion holds

Textmetadata

Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.