ArticleGenetics1996
Identification of immune system and response genes, and novel mutations causing melanotic tumor formation in Drosophila melanogaster.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed, 83 citations in OpenAlex.
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- Collagen IV of basement membrane: V. Bromide-mediated sulfilimine bonds interlock the quaternary structure of NC1-hexamer of scaffolds enabling metazoan evolution.bioRxiv : the preprint server for biology · 2026Article
- High sugar diet-induced fatty acid oxidation potentiates cytokine-dependent cardiac ECM remodeling.The Journal of cell biology · 2024Article
- The UDP-Glycosyltransferase Family inFrontiers in physiology · 2021Article
- Review
- Article
- Triazolo[4,5Computational and structural biotechnology journal · 2018Article
- The GCN2-ATF4 Signaling Pathway Induces 4E-BP to Bias Translation and Boost Antimicrobial Peptide Synthesis in Response to Bacterial Infection.Cell reports · 2017Article
- The role of variant histone H2AV inDevelopment (Cambridge, England) · 2017Article
- 4E-BP is a target of the GCN2-ATF4 pathway during Drosophila development and aging.The Journal of cell biology · 2017Article
- Acute Fasting Regulates Retrograde Synaptic Enhancement through a 4E-BP-Dependent Mechanism.Neuron · 2016Article
- Methods to Examine the Lymph Gland and Hemocytes in Drosophila Larvae.Journal of visualized experiments : JoVE · 2016Article
- Transdifferentiation and Proliferation in Two Distinct Hemocyte Lineages in Drosophila melanogaster Larvae after Wasp Infection.PLoS pathogens · 2016Article
- DNMT3L enables accumulation and inheritance of epimutations in transgenic Drosophila.Scientific reports · 2016Article
- As the fat flies: The dynamic lipid droplets of Drosophila embryos.Biochimica et biophysica acta · 2015Review
- Drosophila Longevity Assurance Conferred by Reduced Insulin Receptor Substrate Chico Partially Requires d4eBP.PloS one · 2015Article
- Basement membrane and cell integrity of self-tissues in maintaining Drosophila immunological tolerance.PLoS genetics · 2014Article
- Article
- Polycomb silencing of the Drosophila 4E-BP gene regulates imaginal disc cell growth.Developmental biology · 2013Article
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We are using Drosophila as a model system for analysis of immunity and tumor formation and have conducted two types of screens using enhancer detector strains to find genes related to these processes; genes expressed in the immune system (type A; hemocytes, lymph glands and fat body) and genes increased in expression by bacterial infection (type B). For type A, tissue-specific reporter gene activity was determined. For type B, a variation of enhancer detection was devised in which beta-galactosidase is assayed spectrophotometrically with and without bacterial infection. Because of immune system involvement in melanotic tumor formation, a third type was hypothesized to be found among types A and B; genes that, when mutated, have a melanotic tumor phenotype. Enhancer detector strains (2800) were screened for type A, 900 for B, and 11 retained for further analysis. Complementation tests, cytological mapping, P-element mobilization, and determination of lethal phase and mutant phenotype have identified six novel genes, Dorothy, wizard, toto, viking, Thor and dappled, and one previously identified gene, Collagen IV. All are associated with reporter gene expression in at least one immune system tissue. Thor has increased expression upon infection. Mutations of wizard and dappled have a melanotic tumor phenotype.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.