ArticleGenetics1996
A novel Drosophila Minute locus encodes ribosomal protein S13.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 9 papers.
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Who cites it
9 citing papers in PubMed, 28 citations in OpenAlex.
- Impact of tRNA-induced proline-to-serine mistranslation on the transcriptome of Drosophila melanogaster.G3 (Bethesda, Md.) · 2024Article
- Ribosomal proteins as unrevealed caretakers for cellular stress and genomic instability.Oncotarget · 2014Review
- Cardiomyopathy is associated with ribosomal protein gene haplo-insufficiency in Drosophila melanogaster.Genetics · 2011Article
- Ribosomal proteins and colorectal cancer.Current genomics · 2007Article
- hDREF regulates cell proliferation and expression of ribosomal protein genes.Molecular and cellular biology · 2007Article
- The ribosomal protein genes and Minute loci of Drosophila melanogaster.Genome biology · 2007Article
- A genetic and molecular characterization of two proximal heterochromatic genes on chromosome 3 of Drosophila melanogaster.Genetics · 2005Article
- Down-regulation of RpS21, a putative translation initiation factor interacting with P40, produces viable minute imagos and larval lethality with overgrown hematopoietic organs and imaginal discs.Molecular and cellular biology · 1999Article
- Ribosomal protein insufficiency and the minute syndrome in Drosophila: a dose-response relationship.Genetics · 1998Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Minutes comprise > 50 phenotypically similar Drosophila mutations believed to affect ribosomal protein genes. Common traits of the Minute phenotype are short and thin bristles, slow development, and recessive lethality. To further investigate the proposed Minute to ribosomal protein correspondence, loss-of-function Minute mutations were induced by P-element mutagenesis. Here, we report a previously undescribed Minute locus that maps to 32A on chromosome 2L; this Minute allele is named P{lacW}M(2)32A1 and the gene M(2)32A. Flies heterozygous for P{lacW}M(2)32A1 have a medium Minute phenotype. The gene interrupted by the P-element insertion was cloned. Sequence analyses revealed that it encodes the Drosophila homologue of eukaryotic ribosomal protein S13. It is a single-copy gene and the level of RPS13 transcript is reduced to approximately 50% in P(lacW) M(2)32A1 heterozygotes. Both transcript level and phenotype are restored to wild type by remobilizing the P-element, demonstrating that the mutation is caused by insertion of the P-element construct. These results further strengthen the notion that Minutes encode ribosomal proteins and demonstrate that P-element mutagenesis is a fruitful approach to use in these studies.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.