ArticleGenetics1996
Los1p, involved in yeast pre-tRNA splicing, positively regulates members of the SOL gene family.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.
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Who cites it
8 citing papers in PubMed, 16 citations in OpenAlex.
- tRNA biology charges to the front.Genes & development · 2010Review
- Enhancer of decapping proteins 1 and 2 are important for translation during heat stress in Saccharomyces cerevisiae.Molecular microbiology · 2009Article
- Division of labor among the yeast Sol proteins implicated in tRNA nuclear export and carbohydrate metabolism.Genetics · 2004Article
- Recognition of nascent RNA by the human La antigen: conserved and divergent features of structure and function.Molecular and cellular biology · 2001Review
- A novel Sinorhizobium meliloti operon encodes an alpha-glucosidase and a periplasmic-binding-protein-dependent transport system for alpha-glucosides.Journal of bacteriology · 1999Article
- Article
- Yeast Los1p has properties of an exportin-like nucleocytoplasmic transport factor for tRNA.Molecular and cellular biology · 1998Article
- tRNA nuclear export in saccharomyces cerevisiae: in situ hybridization analysis.Molecular biology of the cell · 1998Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
To understand the role of Los1p in pre-tRNA splicing, we sought los1 multicopy suppressors. We found SOL1 that suppresses both point and null LOS1 mutations. Since, when fused to the Ga14p DNA-binding domain, Los1p activates transcription, we tested whether Los1p regulates SOL1. We found that las1 mutants have depleted levels of SOL1 mRNA and Sol1p. Thus, LOS1 appears to positively regulate SOL1. SOL1 belongs to a multigene family with at least two additional members, SOL2 and SOL3. Sol proteins have extensive similarity to an unusual group of glucose-6-phosphate dehydrogenases. As the similarities are restricted to areas separate from the catalytic domain, these G6PDs may have more than one function. The SOL family appears to be unessential since cells with a triple disruption of all three SOL genes are viable. SOL gene disruptions negatively affect tRNA-mediated nonsense suppression and the severity increases with the number of mutant SOL genes. However, tRNA levels do not vary with either multicopy SOL genes or with SOL disruptions. Therefore, the Sol proteins affect tRNA expression/ function at steps other than transcription or splicing. We propose that LOS1 regulates gene products involved in tRNA expression/function as well as pre-tRNA splicing.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.