ArticleInternational journal of pancreatology : official journal of the International Association of Pancreatology1996
Granulocyte-colony stimulating factor produced by pancreatic carcinoma.
Article in International journal of pancreatology : official journal of the International Association of Pancreatology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 43 citations in OpenAlex.
- Impact of Prophylactic Use of PEG-rhG-CSF on First-Line Immunochemotherapy in Advanced NSCLC: A Cohort Study.JTO clinical and research reports · 2025Article
- A case of resected anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor with literature review.Surgical case reports · 2024Article
- Review
- A case of granulocyte-colony-stimulating factor-producing gallbladder cancer with lymph node metastasis together with a literature review.Clinical journal of gastroenterology · 2023Review
- Review
- An autopsy case of granulocyte colony-stimulating factor-producing pancreatic adenosquamous carcinoma.Clinical journal of gastroenterology · 2020Article
- Much More than Trousseau Syndrome. The Broad Spectrum of the Pancreatic Paraneoplastic Syndromes.Pathology oncology research : POR · 2018Review
- Distinct pathophysiological cytokine profiles for discrimination between autoimmune pancreatitis, chronic pancreatitis, and pancreatic ductal adenocarcinoma.Journal of translational medicine · 2017Article
- Granulocyte-colony stimulating factor producing anaplastic carcinoma of the pancreas treated by distal pancreatectomy and chemotherapy: report of a case.Surgical case reports · 2015Article
- A case of anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor.Clinical journal of gastroenterology · 2009Article
- Anaplastic carcinoma of the pancreas producing granulocyte-colony stimulating factor: a case report.Journal of medical case reports · 2008Article
- Granulocyte-colony stimulating factor-producing pancreatic cancer: report of a case.Surgery today · 2008Article
- Aggressive Recurrent Pancreatic Cancer Producing Granulocyte Colony-Stimulating Factor.Case reports in gastroenterologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
conclusionA rare case of granulocyte-colony stimulating factor (G-CSF) produced by carcinoma of the pancreas has been reported.
backgroundThis is the first case showing high G-CSF concentration in the aspirated tumor fluid (mucin) at its early stage without leukocytosis.
methodsThe tumor, detected incidentally in a 64-yr-old male, was removed by a distal pancreatectomy. The mass was 7.0 x 6.5 x 4.5 cm, and was histologically diagnosed as cystadenocarcinoma with prominent sarcomatous transformation. It was classified as anaplastic carcinoma.
resultsAfter 4 wk of resection, progressive leukocytosis was observed. Seven weeks after the operations, the peripheral leukocyte count increased to 126,000/mL. After 8 wk of resection, the patient died of recurrence. The serum G-CSF concentration was elevated after recurrence. The preserved mucin contained in the cystic components of the resected specimen had a G-CSF concentration higher than 2400 pg/mL. G-CSF is a known cytokine and an etiologic agent in paraneoplastic syndromes. An early diagnosis can, therefore, be made prior to the manifestation of clinical symptoms by the evaluation of the aspirated tumor fluid. This can lead to the prevention of the paraneoplastic syndrome with inhibitory cytokines in future.
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