ArticleGenetics1996
Gene conversion alone accounts for more than 90% of recombination events at the am locus of Neurospora crassa.
Article in Genetics, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
11 citing papers in PubMed, 32 citations in OpenAlex.
- Meiotic Recombination in Neurospora crassa Proceeds by Two Pathways with Extensive Holliday Junction Migration.PloS one · 2016Article
- Residual recombination in Neurospora crassa spo11 deletion homozygotes occurs during meiosis.Molecular genetics and genomics : MGG · 2013Article
- Use of fluorescent protein to analyse recombination at three loci in Neurospora crassa.Fungal genetics and biology : FG & B · 2012Article
- A crossover hotspot near his-3 in Neurospora crassa is a preferential recombination termination site.Molecular genetics and genomics : MGG · 2012Article
- Complex inheritance of the plasmodial surface anion channel in a Plasmodium falciparum genetic cross.Molecular microbiology · 2009Article
- Persistence and loss of meiotic recombination hotspots.Genetics · 2005Article
- Alleles of the hotspot cog are codominant in effect on recombination in the his-3 region of Neurospora.Genetics · 2004Article
- Recombination at his-3 in Neurospora declines exponentially with distance from the initiator, cog.Genetics · 2002Article
- Recombination events in Neurospora crassa may cross a translocation breakpoint by a template-switching mechanism.Genetics · 2001Article
- Evidence for negative interference: clustering of crossovers close to the am locus in Neurospora crassa among am recombinants.Genetics · 1999Article
- Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have used closely flanking molecular markers located approximately 4 kb distal and 6 kb proximal of the am locus to investigate the incidence of crossover events associated with the generation of prototrophic recombinants in a cross heteroallelic am1 am6. Ninety-three percent of prototrophs were generated by events that did not recombine the molecular markers, indicating that simple conversion accounts for the formation of most prototrophs and that associated crossovers are much less frequent (approximately 0.07) than estimated previously using more distant flanking markers. This suggests that conversion and crossing over during meiosis may arise from distinct mechanisms or that if, as is widely supposed, conversion and crossing over result from alternate modes of resolution of Holliday junctions then, at least for the am locus of Neurospora, the mode of resolution is strongly biased in favor of retaining the parental association of flanking sequences. Because estimates of the association of conversion and crossing over based on more distant gene markers are similar for yeast and Neurospora (approximately 0.35), our observation may have general significance.
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