ArticleGraefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie1996
Susceptibility of human retinal pigment epithelial cells to different viruses.
Article in Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.
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Who cites it
13 citing papers in PubMed, 23 citations in OpenAlex.
- HSV-1 Infection in Retinal Pigment Epithelial Cells: A Possible Contribution to Age-Related Macular Degeneration.Viruses · 2025Review
- Presumed bilateral acute idiopathic maculopathy in a pediatric patient.American journal of ophthalmology case reports · 2025Article
- The Relevance of Bacillary Layer Detachment and Choroidal flow Insufficiency in Unilateral Acute Idiopathic Maculopathy Associated with Hand, Foot, and Mouth Disease: A Case Report.Beyoglu eye journal · 2024Article
- Long-term multimodal imaging in acute posterior multifocal placoid pigment epitheliopathy and association with coxsackievirus exposure.PloS one · 2020Article
- Interplay between IDO1 and iNOS in human retinal pigment epithelial cells.Medical microbiology and immunology · 2019Article
- A review of unilateral acute idiopatic maculopathy related to hand-foot-mouth disease with a representative case.International ophthalmology · 2016Review
- Unilateral acute maculopathy associated with adult onset hand, foot and mouth disease: case report and review of literature.Journal of ophthalmic inflammation and infection · 2015Article
- The retinal pigment epithelium (RPE) induces FasL and reduces iNOS and Cox2 in primary monocytes.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 2014Article
- Multimodality diagnostic imaging in unilateral acute idiopathic maculopathy.Archives of ophthalmology (Chicago, Ill. : 1960) · 2012Article
- Involvement of protein kinase C in phagocytosis of human retinal pigment epithelial cells and induction of matrix metalloproteinase secretion.International ophthalmology · 2009Article
- Influence of viral infection on expression of cell surface antigens in human retinal pigment epithelial cells.Graefe's archive for clinical and experimental ophthalmology = Albrecht von Graefes Archiv fur klinische und experimentelle Ophthalmologie · 1997Article
- Unilateral acute idiopathic maculopathy related to hand-foot-mouth disease: Case report and literature review.Taiwan journal of ophthalmologyArticle
- Multimodal Imaging of Unilateral Acute Maculopathy Associated with Hand, Foot, and Mouth Disease: A Case Series.Case reports in ophthalmologyArticle
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundDifferent viruses have been reported to be involved in retinal diseases in animal systems. In humans, herpes simplex virus and cytomegalovirus have been found to cause retinal disease. Most of the studied viruses are neurotropic. In this study, the in vitro susceptibility of human retinal pigment epithelial cells (RPEC) to representative members of different groups of human pathogenic viruses was investigated.
methodsEarly cultures of RPE C - after two or three passages - were infected with the following viruses: herpes simplex virus (HSV) type 1, human herpesvirus 6 (HHV-6), Epstein-Barr virus (EBV), cytomegalovirus (CMV), adenovirus types 1 and 7, measles virus, parainfluenza virus and coxsackie virus B3.
resultsCultures of RPE C could be infected with neurotropic viruses like HSV or measles virus as well as with typical respiratory viruses like parainfluenza or adenoviruses. Coxsackievirus, an enterovirus, replicated as well as human CMV, whereas EBV and HHV-6, two lymphotropic viruses, failed to infect RPE.
conclusionThese findings suggest that a variety of viruses, including those causing rather common illnesses, might be capable of inducing retinal lesions under certain circumstances due to haematogenous spread during the course of viraemia.
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