ArticleProceedings of the National Academy of Sciences of the United States of America1996
Constitutive overexpression of Cu/Zn superoxide dismutase exacerbates kainic acid-induced apoptosis of transgenic-Cu/Zn superoxide dismutase neurons.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
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Who cites it
22 citing papers in PubMed, 106 citations in OpenAlex.
- Potential impact of stocking density on growth, carcass traits, indicators of biochemical and oxidative stress and meat quality of different broiler breeds.Poultry science · 2021Article
- Backtracked analysis of preleukemic fusion genes and DNA repair foci in umbilical cord blood of children with acute leukemia.Oncotarget · 2018Article
- Cysticercus fasciolaris infection induced oxidative stress and apoptosis in rat liver: a strategy for host-parasite cross talk.Parasitology research · 2016Article
- Paradoxical Roles of Antioxidant Enzymes: Basic Mechanisms and Health Implications.Physiological reviews · 2016Review
- SOD1 Overexpression Preserves Baroreflex Control of Heart Rate with an Increase of Aortic Depressor Nerve Function.Oxidative medicine and cellular longevity · 2016Article
- Role of antioxidant enzymes in redox regulation of N-methyl-D-aspartate receptor function and memory in middle-aged rats.Neurobiology of aging · 2014Article
- Lipopolysaccharide-induced hepatic oxidative injury is not potentiated by knockout of GPX1 and SOD1 in mice.Biochemical and biophysical research communications · 2011Article
- A noradrenergic lesion exacerbates neurodegeneration in a Down syndrome mouse model.Journal of Alzheimer's disease : JAD · 2011Article
- Skeletal muscle-restricted expression of human SOD1 causes motor neuron degeneration in transgenic mice.Human molecular genetics · 2010Article
- Superoxide dismutase 1 modulates expression of transferrin receptor.Journal of biological inorganic chemistry : JBIC : a publication of the Society of Biological Inorganic Chemistry · 2006Article
- Induction of oxidative stress responses by dioxin and other ligands of the aryl hydrocarbon receptor.Dose-response : a publication of International Hormesis Society · 2006Article
- ets-2 promotes the activation of a mitochondrial death pathway in Down's syndrome neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- Effects of toxic doses of glutamate on Cu-Zn and Mn/superoxide dismutases activities in human glioma cell lines.Journal of neuro-oncology · 2005Article
- Global loss of Na,K-ATPase and its nitric oxide-mediated regulation in a transgenic mouse model of amyotrophic lateral sclerosis.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Antioxidant enzymes in blood of patients with Friedreich's ataxia.Archives of disease in childhood · 2002Article
- Elevated Cu/Zn-SOD exacerbates radiation sensitivity and hematopoietic abnormalities of Atm-deficient mice.The EMBO journal · 2001Article
- Upregulation of GABA neurotransmission suppresses hippocampal excitability and prevents long-term potentiation in transgenic superoxide dismutase-overexpressing mice.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- FLP recombinase-mediated induction of Cu/Zn-superoxide dismutase transgene expression can extend the life span of adult Drosophila melanogaster flies.Molecular and cellular biology · 1999Article
- The nature of antioxidant defense mechanisms: a lesson from transgenic studies.Environmental health perspectives · 1998Review
- Altered Ca2+ signaling and mitochondrial deficiencies in hippocampal neurons of trisomy 16 mice: a model of Down's syndrome.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
Cu/Zn superoxide dismutase (Cu/Zn SOD) is a key enzyme in the metabolism of oxygen free radicals. The gene resides on chromosome 21 and is overexpressed in patients with Down syndrome. Cultured neurons of transgenic Cu/Zn SOD (Tg-Cu/Zn SOD) mice with elevated activity of Cu/Zn SOD were used to determine whether constitutive overexpression of Cu/Zn SOD creates an indigenous oxidative stress that predisposes the Tg-Cu/Zn SOD neurons to added insults. Neurons from three independently derived Tg-Cu/Zn SOD strains showed higher susceptibility than nontransgenic neurons to kainic acid (KA)-mediated excitotoxicity, reflected by an earlier onset and enhanced apoptotic cell death. This higher susceptibility of transgenic neurons to KA-mediated apoptosis was associated with a chronic prooxidant state that was manifested by reduced levels of cellular glutathione and altered [Ca2+]i homeostasis. The data are compatible with the thesis that overexpression of Cu/Zn SOD creates chronic oxidative stress in the transgenic neurons, which exacerbates their susceptibility to additional insults such as KA-mediated excitotoxicity.
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