ArticleProceedings of the National Academy of Sciences of the United States of America1996
Clusters of charged residues in protein three-dimensional structures.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 76 citations in OpenAlex.
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- Low complexity regions in the proteins of prokaryotes perform important functional roles and are highly conserved.Nucleic acids research · 2019Article
- Initial Cluster Analysis.Journal of computational biology : a journal of computational molecular cell biology · 2018Article
- Monomeric Camelus dromedarius GSTM1 at low pH is structurally more thermostable than its native dimeric form.PloS one · 2018Article
- ROTAS: a rotamer-dependent, atomic statistical potential for assessment and prediction of protein structures.BMC bioinformatics · 2014Article
- Pyrene: a probe to study protein conformation and conformational changes.Molecules (Basel, Switzerland) · 2011Review
- The structure of DdrB from Deinococcus: a new fold for single-stranded DNA binding proteins.Nucleic acids research · 2010Article
- Predicting small ligand binding sites in proteins using backbone structure.Bioinformatics (Oxford, England) · 2008Article
- Robust recognition of zinc binding sites in proteins.Protein science : a publication of the Protein Society · 2008Article
- Computational methods for biomolecular electrostatics.Methods in cell biology · 2008Article
- Influence of calcium on lipid mixing mediated by influenza hemagglutinin.Archives of biochemistry and biophysics · 2007Article
- Application of new multi-resolution methods for the comparison of biomolecular electrostatic properties in the absence of global structural similarity.Multiscale modeling & simulation : a SIAM interdisciplinary journal · 2006Article
- Statistical signals in bioinformatics.Proceedings of the National Academy of Sciences of the United States of America · 2005Review
- Predicted highly expressed genes in archaeal genomes.Proceedings of the National Academy of Sciences of the United States of America · 2005Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Statistically significant charge clusters (basic, acidic, or of mixed charge) in tertiary protein structures are identified by new methods from a large representative collection of protein structures. About 10% of protein structures show at least one charge cluster, mostly of mixed type involving about equally anionic and cationic residues. Positive charge clusters are very rare. Negative (or histidine-acidic) charge clusters often coordinate calcium, or magnesium or zinc ions [e.g., thermolysin (PDB code: 3tln), mannose-binding protein (2msb), aminopeptidase (1amp)]. Mixed-charge clusters are prominent at interchain contacts where they stabilize quaternary protein formation [e.g., glutathione S-transferase (2gst), catalase (8act), and fructose-1,6-bisphosphate aldolase (1fba)]. They are also involved in protein-protein interaction and in substrate binding. For example, the mixed-charge cluster of aspartate carbamoyl-transferase (8atc) envelops the aspartate carbonyl substrate in a flexible manner (alternating tense and relaxed states) where charge associations can vary from weak to strong. Other proteins with charge clusters include the P450 cytochrome family (BM-3, Terp, Cam), several flavocytochromes, neuraminidase, hemagglutinin, the photosynthetic reaction center, and annexin. In each case in Table 2 we discuss the possible role of the charge clusters with respect to protein structure and function.
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