ArticleNucleic acids research1996
The Drosophila fork head factor directly controls larval salivary gland-specific expression of the glue protein gene Sgs3.
Article in Nucleic acids research, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 50 citations in OpenAlex.
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- Hormonal activation of let-7-C microRNAs via EcR is required for adult Drosophila melanogaster morphology and function.Development (Cambridge, England) · 2012Article
- Genetic control of programmed cell death during animal development.Annual review of genetics · 2009Review
- A novel ecdysone receptor mediates steroid-regulated developmental events during the mid-third instar of Drosophila.PLoS genetics · 2008Article
- PHA-4/FoxA cooperates with TAM-1/TRIM to regulate cell fate restriction in the C. elegans foregut.Developmental biology · 2007Article
- Fork head controls the timing and tissue selectivity of steroid-induced developmental cell death.The Journal of cell biology · 2007Article
- Ecdysone-induced expression of the caspase DRONC during hormone-dependent programmed cell death in Drosophila is regulated by Broad-Complex.The Journal of cell biology · 2002Article
- Functional regulation of glutamine:fructose-6-phosphate aminotransferase 1 (GFAT1) of Drosophila melanogaster in a UDP-N-acetylglucosamine and cAMP-dependent manner.The Biochemical journal · 2001Article
- Spt5 and spt6 are associated with active transcription and have characteristics of general elongation factors in D. melanogaster.Genes & development · 2000Article
- Structure and regulation of the salivary gland secretion protein gene Sgs-1 of Drosophila melanogaster.Genetics · 1999Article
- Building and specializing epithelial tubular organs: the Drosophila salivary gland as a model system for revealing how epithelial organs are specified, form and specialize.Wiley interdisciplinary reviews. Developmental biologyReview
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Authors and funding
4 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The Drosophila Fork head protein participates in salivary gland formation, since salivary glands are missing in fork head embryos. Here we show that the fork head encoded protein binds to an upstream regulatory region of the larval salivary gland glue protein gene Sgs3. Mobility shift assay in the presence of an anti-Fork head antibody demonstrated that the Fork head factor interacts with the TGTTTGC box shown to be involved in tissue-specific Sgs3 expression. Experiments employing a set of oligonucleotide competitors revealed that Fork head binding was prevented by the same single base substitutions that were previously shown to interfere with the TGTTTGC element function in vivo. Furthermore, the anti-Fork head antibody bound to >60 sites of polytene chromosomes, including the puffs of all Sgs genes and Fork head protein was detected in the nuclei of salivary glands of larvae of all examined stages. These data provide experimental evidence for the hypothesis that the protein encoded by the fork head gene is required initially for salivary gland formation and is utilized subsequently in the control of larval genes specifically expressed in this organ.
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