ArticleMolecular and cellular biochemistry1996
Chronic muscle stimulation increases lactate transport in rat skeletal muscle.
Article in Molecular and cellular biochemistry, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 75 citations in OpenAlex.
- Trial
- Association AmongGenes · 2024Article
- Inhibition of monocarboxylate transporters (MCT) 1 and 4 reduces exercise capacity in mice.Physiological reports · 2022Article
- Decreased Blood Glucose and Lactate: Is a Useful Indicator of Recovery Ability in Athletes?International journal of environmental research and public health · 2020Review
- Muscle LIM protein interacts with cofilin 2 and regulates F-actin dynamics in cardiac and skeletal muscle.Molecular and cellular biology · 2009Article
- The deacetylase enzyme SIRT1 is not associated with oxidative capacity in rat heart and skeletal muscle and its overexpression reduces mitochondrial biogenesis.The Journal of physiology · 2009Article
- Testosterone increases lactate transport, monocarboxylate transporter (MCT) 1 and MCT4 in rat skeletal muscle.The Journal of physiology · 2006Article
- Training-induced changes in membrane transport proteins of human skeletal muscle.European journal of applied physiology · 2006Review
- Exercise rapidly increases expression of the monocarboxylate transporters MCT1 and MCT4 in rat muscle.The Journal of physiology · 2004Article
- The concept of maximal lactate steady state: a bridge between biochemistry, physiology and sport science.Sports medicine (Auckland, N.Z.) · 2003Review
- Regulation of fatty acid transport and membrane transporters in health and disease.Molecular and cellular biochemistry · 2002Review
- Giant membrane vesicles as a model to study cellular substrate uptake dissected from metabolism.Molecular and cellular biochemistry · 2002Article
- Coordinately regulated expression of FAT/CD36 and FACS1 in rat skeletal muscle.Molecular and cellular biochemistry · 2001Article
- Lactate transport in skeletal muscle - role and regulation of the monocarboxylate transporter.The Journal of physiology · 1999Review
Corrections and comments
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Authors and funding
4 authors at 3 institutions in 3 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The aim of this study was to examine the effects of chronic low frequency stimulation on the lactate transport across the plasma membrane of the tibialis anterior (TA) muscle of the rat. Stimulating electrodes were implanted on either side of the peroneal nerve in one hindlimb. Chronic stimulation (10 Hz, 50 microsecond bursts, 24h/day) commenced 7 days after surgery, and were continued for 7 days. Animals were then left for 24 h, and thereafter muscles were obtained. Cytochrome C-oxidase activity was increased 1.9-fold in the stimulated TA compared to the control TA (p < 0.05). Lactate transport (zero-trans) was measured in giant sarcolemmal vesicles obtained from the chronically stimulated TA and the control TA. At each of the concentrations used in these studies a significant increase in lactate transport was observed; 2.8-fold increase at 1 mM lactate p < 0.05); 2-fold increases at both 30 mM and 50 mM lactate p < 0.05). These studies have shown that lactate transport capacity is markedly increased in response to chronic muscle contraction.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.