Evidence map›Paper›PMID 8709952›Full record

ArticleMolecular & general genetics : MGG1996

The genetics of the repair of 5-azacytidine-mediated DNA damage in the fission yeast Schizosaccharomyces pombe.

V Hegde, R J McFarlane, E M Taylor, C Price

Abstract read
PubMed Publisher
In one paragraph

Article in Molecular & general genetics : MGG, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 40% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 12 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

V HegdeDepartment of Molecular Biology and Biotechnology, University of Sheffield, U.K.
R J McFarlane
E M Taylor
C Price
University of Sheffield · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

We have recently demonstrated that Schizosaccharomyces pombe cells treated with the nucleoside analogue 5-azacytidine (5-azaC) require previously characterised G2 checkpoint mechanisms for survival. Here we present a survey of known DNA repair mutations which defines those genes required for survival in the presence of 5-azaC. Using a combination of single-mutant and epistasis analyses we find that the excision, mismatch and recombinational repair pathways are all required in some degree for the repair of 5-azaC-mediated DNA damage. There are distinct differences in the epistatic interactions of several of the repair mutations with respect to 5-azaC-mediated DNA damage relative to UV-mediated DNA damage.

Indexed as

Adenosine TriphosphatasesDNA DamageDNA RepairEndodeoxyribonucleasesEscherichia coli ProteinsSaccharomyces cerevisiae ProteinsSchizosaccharomyces pombe ProteinsTranscription FactorsAzacitidineBacterial ProteinsDNA-Binding ProteinsDrug Resistance, MicrobialFungal ProteinsMutationMutS DNA Mismatch-Binding ProteinNucleotidesAdenosine TriphosphatasesAzacitidineBacterial ProteinsDNA-Binding ProteinsEndodeoxyribonucleasesEscherichia coli ProteinsFungal ProteinsMutS DNA Mismatch-Binding ProteinMutS protein, E coliNucleotidesRad12 protein, Coprinus cinereusRAD18 protein, S cerevisiaeRAD2 protein, S cerevisiaeRad51 RecombinaseRHP51 protein, S pombeSaccharomyces cerevisiae ProteinsSchizosaccharomyces pombe ProteinsSWI4 protein, S cerevisiaeTranscription Factors

Identifiers

PMID8709952
OpenAlexW2059729351

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.