ArticleJournal of neurology, neurosurgery, and psychiatry1996
Dynamics of cerebral blood flow and metabolism in patients with cranioplasty as evaluated by 133Xe CT and 31P magnetic resonance spectroscopy.
Article in Journal of neurology, neurosurgery, and psychiatry, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 121 citations in OpenAlex.
- Risk factors for the development of hydrocephalus in traumatic brain injury: a systematic review and meta-analysis.Neurosurgical review · 2025Pooled it
- Assessing human scalp and brain blood flow sensitivities via superficial temporal artery occlusion using speckle contrast optical spectroscopy.APL bioengineering · 2025Article
- Vacuum-assisted scalp repositioning: a novel temporizing approach to acute sinking skin flap syndrome. Illustrative cases.Journal of neurosurgery. Case lessons · 2023Article
- Towards a core outcome set for cranioplasty following traumatic brain injury and stroke 'A systematic review of reported outcomes'.Brain & spine · 2023Article
- Clinical improvement after cranioplasty and its relation to body position and cerebral hemodynamics.Neurosurgical review · 2022Article
- Cranioplasty: A Multidisciplinary Approach.Frontiers in surgery · 2022Review
- Sinking skin syndrome in a decompressive craniectomy series: Clinical and radiological features.Surgical neurology international · 2022Article
- 3D printed customised external cranial plate in a patient with syndrome of trephined: 'a case report'.3D printing in medicine · 2021Article
- Sinking Skin Flap Syndrome following Posttraumatic Hydrocephalus.Case reports in neurological medicine · 2021Article
- Article
- Unexpected complications immediately after cranioplasty.Acute medicine & surgery · 2017Article
- Effects of Early Cranioplasty on the Restoration of Cognitive and Functional Impairments.Annals of rehabilitation medicine · 2017Article
- Metabolic Abnormalities of Erythrocytes as a Risk Factor for Alzheimer's Disease.Frontiers in neuroscience · 2017Review
- Intracerebral Hemorrhagic Infarction after Cranioplasty in a Patient with Sinking Skin Flap Syndrome.Korean journal of neurotrauma · 2016Article
- Sinking flap syndrome with abdominal pain: an atypical presentation.BMJ case reports · 2016Article
- Observational
- Factors influencing the outcome (GOS) in reconstructive cranioplasty.Neurosurgical review · 2016Article
- Unexpected Severe Cerebral Edema after Cranioplasty : Case Report and Literature Review.Journal of Korean Neurosurgical Society · 2015Article
- Temporal changes in CT perfusion values before and after cranioplasty in patients without symptoms related to external decompression: a pilot study.Neuroradiology · 2014Article
- Neurological susceptibility to a skull defect.Surgical neurology international · 2014Review
Corrections and comments
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Authors and funding
6 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveProlonged improvement in neurological and mental disorders has been seen after only cranioplasty in patients initially treated with external decompression for high intracranial pressure. The objective was to evaluate, using 133Xe CT and 31P magnetic resonance spectroscopy (MRS), how restoring the bone itself can influence cerebral blood flow and cerebral energy metabolism after high intracranial pressure is attenuated.
methodsSeven patients (45-65 years old) who had undergone external decompression to prevent uncontrollable intracranial hypertension after acute subarachnoid haemorrhage were evaluated. Cerebral blood flow and metabolic changes were evaluated before and after cranioplasty.
resultsThe ratio of phosphocreatine to inorganic phosphate (PCr/Pi), which is a sensitive index of cerebral energy depletion, was calculated and beta-ATP was measured. The cerebral blood flow value in the thalamus was normalised, from 44 (SD 9) to 56 (SD 8) ml/100 g/min (P < 0.01) and the value in the hemisphere increased from 26 (SD 3) to 29 (SD 4) ml/100 g/min on the side with the bone defect. The PCr/Pi ratio improved greatly from 2.53 (SD 0.45) to 3.01 (SD 0.24) (P < 0.01). On the normal side, the values of cerebral blood flow and PCr/Pi increased significantly (P < 0.01) after cranioplasty, possibly due to transneural suppression. The pH of brain tissue was unchanged bilaterally after cranioplasty.
conclusionCranioplasty should be carried out as soon as oedema has disappeared, because a bone defect itself may decrease cerebral blood flow and disturb energy metabolism.
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Registered trials
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