ArticleThe Journal of cell biology1996
ZP3-dependent activation of sperm cation channels regulates acrosomal secretion during mammalian fertilization.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 28 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
28 citing papers in PubMed, 1 synthesis or guideline pooled it, 140 citations in OpenAlex.
- The Catsper channel and its roles in male fertility: a systematic review.Reproductive biology and endocrinology : RB&E · 2017Pooled it
- The evolutionarily conserved piRNA-producing locus pi6 is required for male mouse fertility.Nature genetics · 2020Article
- Molecular Mechanism Underlying the Action ofFrontiers in cell and developmental biology · 2020Article
- Molecular Basis of Human Sperm Capacitation.Frontiers in cell and developmental biology · 2018Review
- Egg Coat Proteins Across Metazoan Evolution.Current topics in developmental biology · 2018Review
- Review
- Roles of the reproductive tract in modifications of the sperm membrane surface.The Journal of reproduction and development · 2016Review
- Mouse sperm begin to undergo acrosomal exocytosis in the upper isthmus of the oviduct.Developmental biology · 2016Article
- Flow cytometry analysis reveals that only a subpopulation of mouse sperm undergoes hyperpolarization during capacitation.Biology of reproduction · 2015Article
- SLO3 K+ channels control calcium entry through CATSPER channels in sperm.The Journal of biological chemistry · 2014Article
- Intracellular pH in sperm physiology.Biochemical and biophysical research communications · 2014Review
- Isolation of a calcium-binding protein of the acrosomal membrane of bovine spermatozoa.The international journal of biochemistry & cell biology · 2013Article
- Sperm epidermal growth factor receptor (EGFR) mediates α7 acetylcholine receptor (AChR) activation to promote fertilization.The Journal of biological chemistry · 2012Article
- The control of male fertility by spermatozoan ion channels.Annual review of physiology · 2012Review
- Role and regulation of EGFR in actin remodeling in sperm capacitation and the acrosome reaction.Asian journal of andrology · 2011Review
- Characterization of the proteomes associating with three distinct membrane raft sub-types in murine sperm.Proteomics · 2010Article
- Article
- Fertilization: a sperm's journey to and interaction with the oocyte.The Journal of clinical investigation · 2010Review
- Egg coat proteins activate calcium entry into mouse sperm via CATSPER channels.Biology of reproduction · 2009Article
- Phospholipase Cdelta4 is required for Ca2+ mobilization essential for acrosome reaction in sperm.The Journal of cell biology · 2003Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The sperm acrosome reaction is a Ca(2+)-dependent secretory event required for fertilization. Adhesion to the egg's zona pellucida promotes Ca2+ influx through voltage-sensitive channels, thereby initiating secretion. We used potentiometric fluorescent probes to determine the role of sperm membrane potential in regulating Ca2+ entry. ZP3, the glycoprotein agonist of the zona pellucida, depolarizes sperm membranes by activating a pertussis toxin-insensitive mechanism with the characteristics of a poorly selective cation channel. ZP3 also activates a pertussis toxin-sensitive pathway that produces a transient rise in internal pH. The concerted effects of depolarization and alkalinization open voltage-sensitive Ca2+ channels. These observations suggest that mammalian sperm utilize membrane potential-dependent signal transduction mechanisms and that a depolarization pathway is an upstream transducing element coupling adhesion to secretion during fertilization.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.