ArticleThe Journal of cell biology1996
ARIA/HRG regulates AChR epsilon subunit gene expression at the neuromuscular synapse via activation of phosphatidylinositol 3-kinase and Ras/MAPK pathway.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers.
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Who cites it
36 citing papers in PubMed, 129 citations in OpenAlex.
- Single-nuclei sequencing of skeletal muscle reveals subsynaptic-specific transcripts involved in neuromuscular junction maintenance.Nature communications · 2025Article
- Secreted Signaling Molecules at the Neuromuscular Junction in Physiology and Pathology.International journal of molecular sciences · 2021Review
- Extracellular signal-regulated kinases 1 and 2 regulate neuromuscular junction and myofiber phenotypes in mammalian skeletal muscle.Neuroscience letters · 2020Review
- AChR β-Subunit mRNAs Are Stabilized by HuR in a Mouse Model of Congenital Myasthenic Syndrome With Acetylcholinesterase Deficiency.Frontiers in molecular neuroscience · 2020Article
- ErbB4 promotes malignant peripheral nerve sheath tumor pathogenesis via Ras-independent mechanisms.Cell communication and signaling : CCS · 2019Article
- HuR Mediates Changes in the Stability of AChR β-Subunit mRNAs after Skeletal Muscle Denervation.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2015Article
- Neuregulin 1 signalling modulates mGluR1 function in mesencephalic dopaminergic neurons.Molecular psychiatry · 2015Article
- Muscle-derived extracellular signal-regulated kinases 1 and 2 are required for the maintenance of adult myofibers and their neuromuscular junctions.Molecular and cellular biology · 2015Article
- Neuregulin in cardiovascular development and disease.Circulation research · 2012Review
- Molecular control of neuromuscular junction development.Journal of cachexia, sarcopenia and muscle · 2012Article
- Modulation of agrin-induced acetylcholine receptor clustering by extracellular signal-regulated kinases 1 and 2 in cultured myotubes.The Journal of biological chemistry · 2010Article
- Neuregulin 1 in neural development, synaptic plasticity and schizophrenia.Nature reviews. Neuroscience · 2008Review
- Ets-1 regulates radial glia formation during vertebrate embryogenesis.Organogenesis · 2007Article
- The expression of neuregulin and erbB receptors in human skeletal muscle: effects of progressive resistance training.European journal of applied physiology · 2005Article
- Inhibition of MuSK expression by CREB interacting with a CRE-like element and MyoD.Molecular and cellular biology · 2005Article
- Regulation of NMDA receptors by neuregulin signaling in prefrontal cortex.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2005Article
- 14-3-3 gamma associates with muscle specific kinase and regulates synaptic gene transcription at vertebrate neuromuscular synapse.Proceedings of the National Academy of Sciences of the United States of America · 2004Article
- Phosphorylation-elicited quaternary changes of GA binding protein in transcriptional activation.Molecular and cellular biology · 2003Article
- A novel pathway for MuSK to induce key genes in neuromuscular synapse formation.The Journal of cell biology · 2003Article
- Ligand-dependent recruitment of the ErbB4 signaling complex into neuronal lipid rafts.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
AChR-inducing activity (ARIA)/heregulin, a ligand for erbB receptor tyrosine kinases (RTKs), is likely to be one nerve-supplied signal that induces expression of acetylcholine receptor (AChR) genes at the developing neuromuscular junction. Since some RTKs act through Ras and phosphatidylinositol 3-kinase (PI3K), we investigated the role of these pathways in ARIA signaling. Expression of activated Ras or Raf mimicked ARIA-induction of AChR epsilon subunit genes in muscle cells; whereas dominant negative Ras or Raf blocked the effect of ARIA. ARIA rapidly activated erk1 and erk2 and inhibition of both erks also abolished the effect of ARIA. ARIA stimulated association of PI3K with erbB3, expression of an activated PI3K led to ARIA-independent AChR epsilon subunit expression, and inhibition of PI3K abolished the action of ARIA. Thus, synaptic induction of AChR genes requires activation of both Ras/MAPK and PI3K signal transduction pathways.
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