ArticleThe Journal of cell biology1996
Poisson-distributed active fusion complexes underlie the control of the rate and extent of exocytosis by calcium.
Article in The Journal of cell biology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Unbiased Thiol-Labeling and Top-Down Proteomic Analyses Implicate Multiple Proteins in the Late Steps of Regulated Secretion.Proteomes · 2019Article
- Lipid-dependence of target membrane stability during influenza viral fusion.Journal of cell science · 2018Article
- The Role of Phospholipase D in Regulated Exocytosis.The Journal of biological chemistry · 2015Article
- Quantification of exocytosis kinetics by DIC image analysis of cortical lawns.Journal of chemical biology · 2014Article
- A new approach to the molecular analysis of docking, priming, and regulated membrane fusion.Journal of chemical biology · 2011Article
- Enhancement of the Ca(2+)-triggering steps of native membrane fusion via thiol-reactivity.Journal of chemical biology · 2009Article
- Specific lipids supply critical negative spontaneous curvature--an essential component of native Ca2+-triggered membrane fusion.Biophysical journal · 2008Article
- Influence of quantal size and cAMP on the kinetics of quantal catecholamine release from rat chromaffin cells.Biophysical journal · 2007Article
- A kinetic analysis of calcium-triggered exocytosis.The Journal of general physiology · 2001Article
- Exocytotic insertion of calcium channels constrains compensatory endocytosis to sites of exocytosis.The Journal of cell biology · 2000Article
- Sea urchin egg preparations as systems for the study of calcium-triggered exocytosis.The Journal of physiology · 1999Review
- Early requirement for alpha-SNAP and NSF in the secretory cascade in chromaffin cells.The EMBO journal · 1999Article
- Calcium influx is required for endocytotic membrane retrieval.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- A persistent activity-dependent facilitation in chromaffin cells is caused by Ca2+ activation of protein kinase C.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1999Article
- Biochemical and functional studies of cortical vesicle fusion: the SNARE complex and Ca2+ sensitivity.The Journal of cell biology · 1998Article
- The calcium sensitivity of individual secretory vesicles is invariant with the rate of calcium delivery.The Journal of general physiology · 1998Article
- Submaximal responses in calcium-triggered exocytosis are explained by differences in the calcium sensitivity of individual secretory vesicles.The Journal of general physiology · 1998Article
- Ca2+-induced exocytosis in individual human neutrophils: high- and low-affinity granule populations and submaximal responses.The EMBO journal · 1998Article
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Authors and funding
3 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We have investigated the consequences of having multiple fusion complexes on exocytotic granules, and have identified a new principle for interpreting the calcium dependence of calcium-triggered exocytosis. Strikingly different physiological responses to calcium are expected when active fusion complexes are distributed between granules in a deterministic or probabilistic manner. We have modeled these differences, and compared them with the calcium dependence of sea urchin egg cortical granule exocytosis. From the calcium dependence of cortical granule exocytosis, and from the exposure time and concentration dependence of N-ethylmaleimide inhibition, we determined that cortical granules do have spare active fusion complexes that are randomly distributed as a Poisson process among the population of granules. At high calcium concentrations, docking sites have on average nine active fusion complexes.
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