ArticleImmunology1996
Expression of major histocompatibility complex class II antigens on normal porcine intestinal endothelium.
Article in Immunology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
15 citing papers in PubMed, 65 citations in OpenAlex.
- The non-classical major histocompatibility complex II protein SLA-DM is crucial for African swine fever virus replication.Scientific reports · 2023Article
- Assessment of intestinal macromolecular absorption in young piglets to pave the way to oral vaccination: preliminary results.Veterinary research communications · 2022Article
- Early intervention with Bifidobacterium lactis NCC2818 modulates the host-microbe interface independent of the sustained changes induced by the neonatal environment.Scientific reports · 2017Article
- The development and role of microbial-host interactions in gut mucosal immune development.Journal of animal science and biotechnology · 2017Review
- Stress, Nutrition, and Intestinal Immune Responses in Pigs - A Review.Asian-Australasian journal of animal sciences · 2016Article
- The porcine innate immune system: an update.Developmental and comparative immunology · 2014Review
- Rearing environment affects development of the immune system in neonates.Clinical and experimental immunology · 2010Article
- From grunts to words: experiments in laryngeal transplantation.Annals of the Royal College of Surgeons of England · 2007Article
- Porcine isosporosis: infection dynamics, pathophysiology and immunology of experimental infections.Wiener klinische Wochenschrift · 2007Review
- Early immunological changes associated with laryngeal transplantation in a major histocompatibility complex-matched pig model.Clinical and experimental immunology · 2006Article
- The larynx as an immunological organ: immunological architecture in the pig as a large animal model.Clinical and experimental immunology · 2006Article
- Gene expression profiling of jejunal Peyer's patches in juvenile and adult pigs.Mammalian genome : official journal of the International Mammalian Genome Society · 2005Article
- Differential major histocompatibility complex class II locus expression on human laryngeal epithelium.Clinical and experimental immunology · 2003Article
- Professional and non-professional antigen-presenting cells in the porcine small intestine.Immunology · 2000Article
- T-cell populations in the pig intestinal lamina propria: memory cells with unusual phenotypic characteristics.Immunology · 1999Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A novel monoclonal antibody (MIL 11) specific for an antigen expressed on porcine endothelial cells is described. The antigen recognized by MIL 11 is most strongly expressed in the intestine but is also expressed on the capillary endothelium of a wide range of tissues. Using two- and three-colour immunofluorescence microscopy we demonstrated the extensive coexpression of MIL 11 and major histocompatibility complex (MHC) class II antigens on normal porcine capillary endothelium in the intestine, trachea, thymus and small veins, while endothelium of large vessels and the heart were negative for MHC class II. In contrast to humans and rodents, available reagents do not detect MHC class II on the intestinal epithelium of pigs. However, porcine intestinal endothelium expressed both DR and DQ antigens. A population of strongly class II-positive cells was also detected immediately adjacent to the endothelium in the lamina propria. Three-colour immunofluorescence microscopy highlighted the close association between endothelium and intestinal CD4+ T cells. Lamina propria T cells were mainly MHC class II positive, whereas those in the epithelial compartment were MHC class II negative.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.