ArticleImmunology1996
Heat-shock protein expression on the membrane of T cells undergoing apoptosis.
Article in Immunology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 61 citations in OpenAlex.
- Understanding GroEL and DnaK Stress Response Proteins as Antigens for Bacterial Diseases.Vaccines · 2020Review
- Membrane-Associated Heat Shock Proteins in Oncology: From Basic Research to New Theranostic Targets.Cells · 2020Review
- Stress proteins in the pathogenesis of spondyloarthritis.Rheumatology international · 2019Review
- Various forms of tissue damage and danger signals following hematopoietic stem-cell transplantation.Frontiers in immunology · 2015Review
- Innate and Adaptive Responses to Heat Shock Proteins in Behcet's Disease.Genetics research international · 2013Review
- Behçet's disease (Adamantiades-Behçet's disease).Clinical & developmental immunology · 2011Review
- Roles of heat shock proteins and gamma delta T cells in inflammation.American journal of respiratory cell and molecular biology · 2008Review
- Proteins pattern alteration in AZT-treated K562 cells detected by two-dimensional gel electrophoresis and peptide mass fingerprinting.Proteome science · 2006Article
- Expression of 60 kDa heat shock protein (Hsp60) on plasma membrane of Daudi cells.Molecular and cellular biochemistry · 2004Article
- Translocation of cytoplasmic HSP70 onto the surface of EL-4 cells during apoptosis.Cell proliferation · 2002Article
- Spontaneous apoptosis and expression of cell surface heat-shock proteins in cultured EL-4 lymphoma cells.Cell proliferation · 1999Article
- Plasma membrane expression of heat shock protein 60 in vivo in response to infection.Infection and immunity · 1999Article
- Article
- Correlation of the EL-4 lymphoma cell apoptosis with the expression of heat shock proteins.Doklady biological sciences : proceedings of the Academy of Sciences of the USSR, Biological sciences sectionsArticle
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Heat-shock proteins (hsp) represent a highly conserved family of proteins, normally localized in the cytoplasm and nucleus, whose expression is induced in situations involving cell stress. This paper reports the unusual translocation of hsp to the cell membrane of T cells undergoing apoptosis. We observed that glucocorticosteroid-induced thymocyte death is associated to the surface expression of hsp 60 and hsp 70 in a discrete fraction of apoptotic cells. hsp surface expression is closely related to a thymic subset of immature CD3low/- T cells. The expression of surface hsp 60 appears early after treatment with dexamethasone (3 hr) whereas the membrane expression of hsp 70 follows different kinetics and peaks later. Morphological analysis of the hsp+ apoptotic cells suggest that this subset represents late-stage apoptotic cells at their minimal volume before fragmentation into apoptotic bodies. Membrane expression of hsp is also associated with apoptosis in peripheral blood mononuclear cells from AIDS patients cultured in vitro. Altogether, we show that a discrete fraction of cells undergoing apoptosis expresses membrane hsp 60 and hsp 70, supporting the hypothesis that apoptosis causes a radical alteration in the expression of cell surface molecules. Surface hsp expressed during apoptosis may constitute a novel immune-context able to generate packages of self- and exogenous antigens, originating from degradation of altered cells.
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