ArticleGut1996
Acute epithelial injury in the rat small intestine in vivo is associated with expanded expression of transforming growth factor alpha and beta.
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.
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Who cites it
21 citing papers in PubMed, 67 citations in OpenAlex.
- Review
- Mucosal healing progression after acute colitis in mice.World journal of gastroenterology · 2019Article
- New targets for mucosal healing and therapy in inflammatory bowel diseases.Mucosal immunology · 2014Review
- SMAD regulatory networks construct a balanced immune system.Immunology · 2013Review
- Use of butyrate or glutamine in enema solution reduces inflammation and fibrosis in experimental diversion colitis.World journal of gastroenterology · 2012Article
- Article
- Unfractionated heparin and new heparin analogues from ascidians (chordate-tunicate) ameliorate colitis in rats.The Journal of biological chemistry · 2009Article
- From the diet to the nucleus: vitamin A and TGF-beta join efforts at the mucosal interface of the intestine.Seminars in immunology · 2009Review
- Sensory neuropeptides and epithelial cell restitution: the relevance of SP- and CGRP-stimulated mast cells.International journal of colorectal disease · 2008Article
- Epithelial restitution and wound healing in inflammatory bowel disease.World journal of gastroenterology · 2008Review
- Responsiveness of intestinal epithelial cell turnover to TGF-alpha after bowel resection in a rat is correlated with EGF receptor expression along the villus-crypt axis.Pediatric surgery international · 2008Article
- Substance P induces intestinal wound healing via fibroblasts--evidence for a TGF-beta-dependent effect.International journal of colorectal disease · 2007Article
- TGF-{beta}-dependent CD103 expression by CD8(+) T cells promotes selective destruction of the host intestinal epithelium during graft-versus-host disease.The Journal of experimental medicine · 2005Article
- Long term endocrine regulation of nucleoside transporters in rat intestinal epithelial cells.The Journal of general physiology · 2004Article
- Increased expression of HGF and c-met in rat small intestine during recovery from methotrexate-induced mucositis.British journal of cancer · 2000Article
- Myofibroblasts: paracrine cells important in health and disease.Transactions of the American Clinical and Climatological Association · 2000Review
- EGF and TGF-beta1 gene expression in chronically rejecting small bowel transplants.Digestive diseases and sciences · 1999Article
- Cytokines in Salmonella infection.Folia microbiologica · 1999Article
- Interactions between stromal cell--derived keratinocyte growth factor and epithelial transforming growth factor in immune-mediated crypt cell hyperplasia.The Journal of clinical investigation · 1998Article
- Growth control mechanisms in normal and transformed intestinal cells.Philosophical transactions of the Royal Society of London. Series B, Biological sciences · 1998Review
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
backgroundPrevious studies have shown the importance of transforming growth factors alpha and beta (TGF alpha and TGF beta) in modulating epithelial cell restitution after injury in vitro.
aimTo investigate the role of the growth factors TGF alpha and TGF beta after acute epithelial injury in vivo.
methodsAn in vivo model of phytohaemagglutinin (PHA) induced acute epithelial injury in rat small intestine was used. Epithelial cell turnover was assessed by autoradiography and liquid scintillation counting of thymidine uptake. Expression of TGF alpha and TGF beta was assessed by immunohistochemistry.
resultsAn expansion of the proliferative compartment and increased turnover of intestinal epithelial cells was seen in rats with PHA induced intestinal epithelial injury. Expression of TGF alpha and TGF beta peptides was shown in both the epithelial cell and lamina propria compartment. Different patterns of TGF alpha and TGF beta expression were seen, however, within the epithelium of rats with acute intestinal injury compared with untreated controls, while the expression of these peptides within the lamina propria was not changed.
conclusionsThese findings suggest that acute intestinal epithelial cell injury in vivo is associated with compensatory changes in expression of TGF alpha and TGF beta in the epithelial cell compartment, while the lamina propria does not seem to be significantly affected.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.