ArticleGut1996
Eradication of Helicobacter pylori in patients with duodenal ulcer lowers basal and peak acid outputs to gastrin releasing peptide and pentagastrin.
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.
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Who cites it
24 citing papers in PubMed, 82 citations in OpenAlex.
- Effectiveness of acid suppression in preventing gastroesophageal reflux disease (GERD) after successful treatment of Helicobacter pylori infection.Digestive diseases and sciences · 2001Trial
- The Physiology of the Gastric Parietal Cell.Physiological reviews · 2020Review
- Review
- Article
- IL1B induced Smad 7 negatively regulates gastrin expression.PloS one · 2011Article
- Effect of interleukin-8 on histamine release from totally isolated vascularly perfused rat stomach.Journal of gastroenterology · 2005Article
- The diurnal profile of gastric pepsin activity is reduced with Helicobacter pylori infection.Digestive diseases and sciences · 2004Article
- Inhibitory potency of twice-a-day omeprazole on gastric acidity is enhanced by eradication of H. pylori in duodenal ulcer patients.Digestive diseases and sciences · 2003Article
- Neutrophil-derived hydroxyl radicals mediate interleukin-8-induced increases in tetragastrin-stimulated acid secretion in rats.Digestive diseases and sciences · 2003Article
- Protective effect of ammonia against reflux esophagitis in rats.Digestive diseases and sciences · 2001Article
- Helicobacter pylori infection and gastrointestinal hormones:a review.World journal of gastroenterology · 2000Article
- Mechanisms involved in Helicobacter pylori induced duodenal ulcer disease:an overview.World journal of gastroenterology · 2000Article
- Effect of Helicobacter pylori eradication on 24-hour gastric pH and duodenal gastric metaplasia.Digestive diseases and sciences · 2000Article
- Article
- Review
- Interleukin-8 enhances tetragastrin-stimulated acid secretion in vivo.Digestive diseases and sciences · 1998Article
- Review
- [1997 gastroenterology update--I].Medizinische Klinik (Munich, Germany : 1983) · 1998Article
- Helicobacter pylori and duodenal ulcers.Gut · 1997Article
- Gastric acid secretion.Gut · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundPatients with duodenal ulcer (DU) have high basal (BAO) and peak (PAO) acid outputs. The effect of Helicobacter pylori eradication on these variables is unclear.
aimTo discover if gastric acid hypersecretion in patients with DU is caused by H pylori. PATIENTS AND
methodsBAO, gastrin releasing peptide (GRP), and pentagastrin stimulated PAO in 10 H pylori negative controls, and in 10 H pylori positive patients with DU was measured before and six months after H pylori eradication. H pylori status was determined by histology, culture, and by the 13C-urea breath test. After collecting a 30 minute basal aspirate, GRP 40 pmol/kg/h was infused for 45 minutes, and after a 30 minute washout, pentagastrin 6 micrograms/kg was injected intramuscularly.
resultsBasal and stimulated acid output (PAOGRP and PAOPg) were significantly higher in H pylori positive DU than in H pylori negative controls. Six months after H pylori eradication, basal and stimulated acid outputs were all significantly lower than before H pylori eradication.
conclusionsThis study has shown that BAO, PAOGRP, and PAOPg are higher in H pylori positive DU than in H pylori negative controls. All decreased significantly six months after H pylori eradication, to fall within the range of controls. These results are compatible with a hypothesis that acid hypersecretion in duodenal ulcer disease is caused by H pylori infection.
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