ArticleGut1996
HLA class II gene frequencies in Crohn's disease: a population based analysis in Germany.
Article in Gut, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers, 2 of them syntheses that pooled it.
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Who cites it
16 citing papers in PubMed, 2 syntheses or guidelines pooled it, 79 citations in OpenAlex.
- Association of HLA-DRB1 amino acid residues with giant cell arteritis: genetic association study, meta-analysis and geo-epidemiological investigation.Arthritis research & therapy · 2015Pooled it
- Pooled it
- A powerful approach to identify replicable variants in genome-wide association studies.American journal of human genetics · 2024Article
- Outcome differences in HPV-driven head and neck squamous cell carcinoma attributable to altered human leukocyte antigen frequencies.Frontiers in oncology · 2023Article
- Autoimmune and viral risk factors are associated with achalasia: A case-control study.Neurogastroenterology and motility · 2022Article
- Role of HLA typing on Crohn's disease pathogenesis.Annals of medicine and surgery (2012) · 2015Article
- Integrating genetic and gene expression evidence into genome-wide association analysis of gene sets.Genome research · 2012Article
- Genetics of inflammatory bowel disease: current status and future directions.Canadian journal of gastroenterology = Journal canadien de gastroenterologie · 2006Review
- Frequency and significance of granulomas in a cohort of incident cases of Crohn's disease.Gut · 2005Article
- Progress in searching for susceptibility gene for inflammatory bowel disease by positional cloning.World journal of gastroenterology · 2003Review
- Relationship between the tumor necrosis factor alpha polymorphism and the serum C-reactive protein levels in inflammatory bowel disease.Immunogenetics · 2003Article
- HLA class II haplotype associations with inflammatory bowel disease in Jewish (Ashkenazi) and non-Jewish caucasian populations.Human immunology · 2000Article
- Article
- Inflammatory bowel disease: definition, epidemiology, etiologic aspects, and immunogenetic studies.World journal of gastroenterology · 1998Article
- Article
- Polymorphism of motilin gene in patients with Crohn's disease.Digestive diseases and sciences · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
backgroundUlcerative colitis is the only known inflammatory bowel disease associated with particular HLA alleles. Whereas the association with the HLA-DRB1*15 allele has been described in several independent studies for ulcerative colitis, no contribution of HLA alleles to susceptibility in Crohn's disease has yet been shown.
aimThis study was designed to study the strength of association of HLA class II alleles as risk markers for Crohn's disease in a homogenous population in Germany. PATIENTS: A total of 4251 randomly selected control subjects, and 162 unrelated subjects with Crohn's disease were studied. Subjects were studied for their HLA-DRB1, HLA-DQA1, and HLA-DQB1 alleles.
methodHLA DNA typing was performed after locus specific amplification with the polymerase chain reaction and reverse dot blot hybridisation.
resultsThe HLA-DRB1*07 was the only HLA class II allele found to be significantly associated with Crohn's disease (relative risk (RR) = 1.9, 95% CI: 1.66 to 2.14; p = 0.0001). This association remained significant after correction for the number of DRB1 alleles compared. In patients with disease onset before 35 years the RR for the disease in HLA-DRB1*07 positive subjects was found to be higher (RR = 3.1, 95% CI: 2.44 to 3.76). The HLA-DRB1*03 was significantly decreased in frequency in Crohn's disease (RR = 0.5, 95% CI: 0.39 to 0.61; p = 0.0028).
conclusionThe HLA-DRB1*07 allele provides risk for the disease especially in patients with younger ages of onset. These data also provide indirect evidence for an immunogenetically based heterogeneity of the disease.
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