Trial reportBritish journal of clinical pharmacology1995
Actions of terfenadine and cimetidine on histamine wheal formation.
Trial report in British journal of clinical pharmacology, 1995. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
0 citing papers in PubMed, 1 citations in OpenAlex.
No citing paper in PubMed yet.
Corrections and comments
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Authors and funding
1 author at 1 institution in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
1. A Latin square design was used to compare the effects of four masked oral drugs, placebo, cimetidine, terfenadine and cimetidine plus terfenadine, at single standard doses against histamine injected at concentrations of 0.3 mM and 0.074 mM subepidermally in eight healthy volunteers studied at weekly intervals. 2. Wheal growth occurred in three phases, an initial delay, a phase of rapid growth where drugs were effective, and a phase of slow growth where there were no significant drug effects. 3. Terfenadine was an effective antihistamine. 4. The data were consistent with a terfenadine effect continued into the next treatment block. 5. Under these conditions cimetidine apparently reduced the effects of terfenadine during the rapid wheal growth phase both simultaneously and after a week's interval from terfenadine dosing.
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