ArticleMammalian genome : official journal of the International Mammalian Genome Society1996
Sensitivity to dietary obesity linked to a locus on chromosome 15 in a CAST/Ei x C57BL/6J F2 intercross.
Article in Mammalian genome : official journal of the International Mammalian Genome Society, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 62 citations in OpenAlex.
- The Genetic Elements of the Obesity Paradox in Atherosclerosis Identified in an Intercross Between Hyperlipidemic Mouse Strains.International journal of molecular sciences · 2025Article
- Adiposity QTL Adip20 decomposes into at least four loci when dissected using congenic strains.PloS one · 2017Article
- Article
- The importance of context to the genetic architecture of diabetes-related traits is revealed in a genome-wide scan of a LG/J × SM/J murine model.Mammalian genome : official journal of the International Mammalian Genome Society · 2011Article
- Biology of obesity: lessons from animal models of obesity.Journal of biomedicine & biotechnology · 2011Review
- Metabolic syndrome components in murine models.Endocrine, metabolic & immune disorders drug targets · 2010Review
- Further understanding of fat biology: lessons from a fat fly.Experimental & molecular medicine · 2010Review
- Positional cloning of "Lisch-Like", a candidate modifier of susceptibility to type 2 diabetes in mice.PLoS genetics · 2008Article
- Genetic complexity of an obesity QTL ( Fob3) revealed by detailed genetic mapping.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- A large-sample QTL study in mice: II. Body composition.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- A large-sample QTL study in mice: I. Growth.Mammalian genome : official journal of the International Mammalian Genome Society · 2004Article
- Loci on chromosomes 2, 4, 9, and 16 for body weight, body length, and adiposity identified in a genome scan of an F2 intercross between the 129P3/J and C57BL/6ByJ mouse strains.Mammalian genome : official journal of the International Mammalian Genome Society · 2003Article
- Nutrient preference and diet-induced adiposity in C57BL/6ByJ and 129P3/J mice.Physiology & behavior · 2001Article
- Genome scan for human obesity and linkage to markers in 20q13.American journal of human genetics · 1999Article
- Quantitative trait loci affecting body weight and fatness from a mouse line selected for extreme high growth.Genetics · 1998Article
Corrections and comments
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Authors and funding
3 authors at 2 institutions in 1 country.
Funding
Abstract
Details of a new model of diet-dependent polygenic obesity are presented. CAST/Ei (Mus m. castaneus) mice remain lean after 12 weeks on a high-fat (32 kcal% fat) diet, while C57BL/6J mice become obese. The genes responsible for the obesity segregate in an F2 population derived from an intercross between CAST/Ei and C57BL/6J mice. Quantitative trait analysis, with simple sequence length polymorphisms (SSLPs) at loci previously linked to rodent obesities, identified a quantitative trait locus (QTL) on Chromosome (Chr) 15, accounting for approximately 9% of the variance in adiposity and 14% of the variance in mesenteric depot size. This locus appears to be at the same location as the dietary obesity-3 (Do3) locus controlling body fat content, which was previously identified in an F2 population derived from an SWR/J x AKR/J cross. This is also at the same location as the multigenic obesity-4 (Mob4) locus found in BSB mice, which display spontaneous polygenic obesity. Suggestive linkage also was found at loci close to the single gene mutations Ay on Chr 2 and tub on Chr 7.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.