ArticleProceedings of the National Academy of Sciences of the United States of America1996
Calmodulin controls adaptation of mechanoelectrical transduction by hair cells of the bullfrog's sacculus.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 26 papers.
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Who cites it
26 citing papers in PubMed, 67 citations in OpenAlex.
- Mechanotransduction in mammalian sensory hair cells.Molecular and cellular neurosciences · 2022Review
- A Bundle of Mechanisms: Inner-Ear Hair-Cell Mechanotransduction.Trends in neurosciences · 2019Review
- Fast intensity adaptation enhances the encoding of sound in Drosophila.Nature communications · 2018Article
- Adaptation Independent Modulation of Auditory Hair Cell Mechanotransduction Channel Open Probability Implicates a Role for the Lipid Bilayer.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2016Article
- Active amplification in insect ears: mechanics, models and molecules.Journal of comparative physiology. A, Neuroethology, sensory, neural, and behavioral physiology · 2015Review
- Identifying components of the hair-cell interactome involved in cochlear amplification.BMC genomics · 2009Article
- Distribution of frequencies of spontaneous oscillations in hair cells of the bullfrog sacculus.Biophysical journal · 2009Article
- Auditory transduction in the mouse.Pflugers Archiv : European journal of physiology · 2007Review
- Spontaneous oscillation by hair bundles of the bullfrog's sacculus.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2003Article
- Hair-bundle movements elicited by transepithelial electrical stimulation of hair cells in the sacculus of the bullfrog.Proceedings of the National Academy of Sciences of the United States of America · 2003Article
- Identification of genes expressed in the Xenopus inner ear.Cellular and molecular biology (Noisy-le-Grand, France) · 2001Article
- Myosin VIIA is specifically associated with calmodulin and microtubule-associated protein-2B (MAP-2B).The Biochemical journal · 2001Article
- Putting ion channels to work: mechanoelectrical transduction, adaptation, and amplification by hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Two mechanisms for transducer adaptation in vertebrate hair cells.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The endogenous calcium buffer and the time course of transducer adaptation in auditory hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Regulation of free Ca2+ concentration in hair-cell stereocilia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Imaging odor-induced calcium transients in single olfactory cilia: specificity of activation and role in transduction.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Myosin Ibeta is located at tip link anchors in vestibular hair bundles.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Plasma membrane Ca2+-ATPase extrudes Ca2+ from hair cell stereocilia.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1998Article
- Myosin VIIA is required for aminoglycoside accumulation in cochlear hair cells.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Deflection of the mechanically sensitive hair bundle atop a hair cell opens transduction channels, some of which subsequently reclose during a Ca2+-dependent adaptation process. Myosin I in the hair bundle is thought to mediate this adaptation; in the bullfrog's hair cell, the relevant isozyme may be the 119-kDa amphibian myosin I beta. Because this molecule resembles other forms of myosin I, we hypothesized that calmodulin, a cytoplasmic receptor for Ca2+, regulates the ATPase activity of myosin. We identified an approximately 120-kDa calmodulin-binding protein that shares with hair-bundle myosin I the properties of being photolabeled by vanadate-trapped uridine nucleotides and immunoreactive with a monoclonal antibody raised against mammalian myosin I beta. To investigate the possibility that calmodulin mediates Ca2+-dependent adaptation, we inhibited calmodulin action and measured the results with two distinct assays. Calmodulin antagonists increased photolabeling of hair-bundle myosin I by nucleotides. In addition, when introduced into hair cells through recording electrodes, calmodulin antagonists abolished adaptation to sustained mechanical stimuli. Our evidence indicates that calmodulin binds to and controls the activity of hair-bundle myosin I, the putative adaptation motor.
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