ArticleProceedings of the National Academy of Sciences of the United States of America1996
Detection of sub-8-nm movements of kinesin by high-resolution optical-trap microscopy.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 34 papers.
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Who cites it
34 citing papers in PubMed.
- Mapping Nanoscale Forces and Potentials in Live Cells with Microsecond 3D Single-Particle Tracking.Chemical & biomedical imaging · 2026Article
- Article
- Cargo surface fluidity can reduce inter-motor mechanical interference, promote load-sharing and enhance processivity in teams of molecular motors.PLoS computational biology · 2022Article
- A mechanochemical model of the forward/backward movement of motor protein kinesin-1.The Journal of biological chemistry · 2022Article
- Tuning ensemble-averaged cargo run length via fractional change in mean kinesin number.Physical biology · 2021Article
- The mechanochemistry of the kinesin-2 KIF3AC heterodimer is related to strain-dependent kinetic properties of KIF3A and KIF3C.Proceedings of the National Academy of Sciences of the United States of America · 2020Article
- Cargo diffusion shortens single-kinesin runs at low viscous drag.Scientific reports · 2019Article
- A modified active Brownian dynamics model using asymmetric energy conversion and its application to the molecular motor system.Journal of biological physics · 2013Article
- Force mapping during the formation and maturation of cell adhesion sites with multiple optical tweezers.PloS one · 2013Article
- Detection of Steps in Single Molecule Data.Cellular and molecular bioengineering · 2012Article
- A structural perspective on the dynamics of kinesin motors.Biophysical journal · 2011Article
- Drag force as a tool to test the active mechanical response of PC12 neurites.Biophysical journal · 2010Article
- Single molecule studies of homologous recombination.Molecular bioSystems · 2008Review
- Fast fluorescence laser tracking microrheometry. I: instrument development.Biophysical journal · 2008Article
- Two distinct modes of processive kinesin movement in mixtures of ATP and AMP-PNP.The Journal of general physiology · 2007Article
- Mechanical control of the directional stepping dynamics of the kinesin motor.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- Kinesin motor mechanics: binding, stepping, tracking, gating, and limping.Biophysical journal · 2007Review
- On the hand-over-hand mechanism of kinesin.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Resource Letter: LBOT-1: Laser-based optical tweezers.American journal of physics · 2003Article
- Kinesin: a molecular motor with a spring in its step.Proceedings. Biological sciences · 2002Review
Corrections and comments
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Authors and funding
4 authors.
Funding
Abstract
Kinesin is a molecular motor that transports organelles along microtubules. This enzyme has two identical 7-nm-long motor domains, which it uses to move between consecutive tubulin binding sites spaced 8 nm apart along a microtubular protofilament. The molecular mechanism of this movement, which remains to be elucidated, may be common to all families of motor proteins. In this study, a high-resolution optical-trap microscope was used to measure directly the magnitude of abrupt displacements produced by a single kinesin molecule transporting a microscopic bead. The distribution of magnitudes reveals that kinesin not only undergoes discrete 8-nm movements, in agreement with previous work [Svoboda, K., Schmidt, C. F., Schnapp, B. J. & Block, S.M. (1993) Nature (London) 365, 721-727], but also frequently exhibits smaller movements of about 5 nm. A possible explanation for these unexpected smaller movements is that kinesin's movement from one dimer to the next along a protofilament involves at least two distinct events in the mechanical cycle.
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