ReviewProceedings of the National Academy of Sciences of the United States of America1996
Going mobile: microtubule motors and chromosome segregation.
Review in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
53 citing papers in PubMed, 173 citations in OpenAlex.
- Archaeal Cytoskeletal Protein CetZ1 Influences Assembly of the Motility Machinery.Molecular microbiology · 2026Article
- Article
- Article
- Stability and robustness of kinetochore dynamics under sudden perturbations and stochastic influences.Scientific reports · 2025Article
- Diversity and Potential Multifunctionality of Archaeal CetZ Tubulin-like Cytoskeletal Proteins.Biomolecules · 2023Article
- Light-Powered Reactivation of Flagella and Contraction of Microtubule Networks: Toward Building an Artificial Cell.ACS synthetic biology · 2021Article
- Meiosis-Specific Functions of Kinesin Motors in Cohesin Removal and Maintenance of Chromosome Integrity in Budding Yeast.Molecular and cellular biology · 2020Article
- Novel EM based ML Kalman estimation framework for superresolution of stochastic three-states microtubule signal.BMC systems biology · 2018Article
- Tctex-1, a novel interaction partner of Kidney Injury Molecule-1, is required for efferocytosis.Journal of cellular physiology · 2018Article
- Bidirectional motility of kinesin-5 motor proteins: structural determinants, cumulative functions and physiological roles.Cellular and molecular life sciences : CMLS · 2018Review
- GSK-3β Phosphorylation of Cytoplasmic Dynein Reduces Ndel1 Binding to Intermediate Chains and Alters Dynein Motility.Traffic (Copenhagen, Denmark) · 2015Article
- The Arabidopsis kinesin gene AtKin-1 plays a role in the nuclear division process during megagametogenesis.Plant cell reports · 2014Article
- Novel piperazine-based compounds inhibit microtubule dynamics and sensitize colon cancer cells to tumor necrosis factor-induced apoptosis.The Journal of biological chemistry · 2014Article
- Meroterpenes from marine invertebrates: structures, occurrence, and ecological implications.Marine drugs · 2013Review
- The dynamic cytoskeleton of the developing male germ cell.Biology of the cell · 2012Review
- Midzone organization restricts interpolar microtubule plus-end dynamics during spindle elongation.EMBO reports · 2009Article
- Reverse genetic studies of mitochondrial DNA-based diseases using a mouse model.Proceedings of the Japan Academy. Series B, Physical and biological sciences · 2008Review
- Dynein-mediated pulling forces drive rapid mitotic spindle elongation in Ustilago maydis.The EMBO journal · 2006Article
- Mitochondria-related male infertility.Proceedings of the National Academy of Sciences of the United States of America · 2006Article
- Comprehensive comparative analysis of kinesins in photosynthetic eukaryotes.BMC genomics · 2006Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Proper chromosome segregation in eukaryotes depends upon the mitotic and meiotic spindles, which assemble at the time of cell division and then disassemble upon its completion. These spindles are composed in large part of microtubules, which either generate force by controlled polymerization and depolymerization or transduce force generated by molecular microtubule motors. In this review, we discuss recent insights into chromosome segregation mechanisms gained from the analyses of force generation during meiosis and mitosis. These analyses have demonstrated that members of the kinesin superfamily and the dynein family are essential in all organisms for proper chromosome and spindle behavior. It is also apparent that forces generated by microtubule polymerization and depolymerization are capable of generating forces sufficient for chromosome movement in vitro; whether they do so in vivo is as yet unclear. An important realization that has emerged is that some spindle activities can be accomplished by more than one motor so that functional redundancy is evident. In addition, some meiotic or mitotic movements apparently occur through the cooperative action of independent semiredundant processes. Finally, the molecular characterization of kinesin-related proteins has revealed that variations both in primary sequence and in associations with other proteins can produce motor complexes that may use a variety of mechanisms to transduce force in association with microtubules. Much remains to be learned about the regulation of these activities and the coordination of opposing and cooperative events involved in chromosome segregation; this set of problems represents one of the most important future frontiers of research.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.