ArticleInfection and immunity1996
Molecular basis of size and antigenic variation of a Mycoplasma hominis adhesin encoded by divergent vaa genes.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
40 citing papers in PubMed, 93 citations in OpenAlex.
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- SARS-CoV-2, Zika viruses and mycoplasma: Structure, pathogenesis and some treatment options in these emerging viral and bacterial infectious diseases.Biochimica et biophysica acta. Molecular basis of disease · 2021Article
- Cardiothoracic Transplant Recipient Mycoplasma hominis: An Uncommon Infection with Probable Donor Transmission.EBioMedicine · 2017Article
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- Identification of a gene in Mycoplasma hominis associated with preterm birth and microbial burden in intraamniotic infection.American journal of obstetrics and gynecology · 2015Article
- Mycoplasma pulmonis Vsa proteins and polysaccharide modulate adherence to pulmonary epithelial cells.FEMS microbiology letters · 2012Article
- In Mycoplasma hominis the OppA-mediated cytoadhesion depends on its ATPase activity.BMC microbiology · 2011Article
- Adhesive activity of the haemophilus cryptic genospecies cha autotransporter is modulated by variation in tandem Peptide repeats.Journal of bacteriology · 2011Article
- Genetic variability of the P120' surface protein gene of Mycoplasma hominis isolates recovered from Tunisian patients with uro-genital and infertility disorders.BMC infectious diseases · 2007Article
- Array-based genomic comparative hybridization analysis of field strains of Mycoplasma hyopneumoniae.Journal of bacteriology · 2007Article
- Distinctive repertoire of contingency genes conferring mutation- based phase variation and combinatorial expression of surface lipoproteins in Mycoplasma capricolum subsp. capricolum of the Mycoplasma mycoides phylogenetic cluster.Journal of bacteriology · 2006Article
- Mycoplasmas and ureaplasmas as neonatal pathogens.Clinical microbiology reviews · 2005Review
- Association of a major protein antigen of Mycoplasma arthritidis with virulence.Infection and immunity · 2005Article
- The vaa locus of Mycoplasma hominis contains a divergent genetic islet encoding a putative membrane protein.BMC microbiology · 2004Article
- Identification of a 349-kilodalton protein (Gli349) responsible for cytadherence and glass binding during gliding of Mycoplasma mobile.Journal of bacteriology · 2004Article
- Multiple promoter inversions generate surface antigenic variation in Mycoplasma penetrans.Journal of bacteriology · 2003Article
- Molecular heterogeneity of Ehrlichia chaffeensis isolates determined by sequence analysis of the 28-kilodalton outer membrane protein genes and other regions of the genome.Infection and immunity · 2003Article
- Surface diversity in Mycoplasma agalactiae is driven by site-specific DNA inversions within the vpma multigene locus.Journal of bacteriology · 2002Article
- Identification and functional mapping of the Mycoplasma fermentans P29 adhesin.Infection and immunity · 2002Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
The molecular basis for the size and antigenic diversity of the variable adherence-associated (Vaa) antigen, a major surface protein and a putative adhesin (of Mycoplasma hominis, is described. Size-variant alleles of the single-copy vaa gene encode abundant surface lipoproteins containing one to four nearly identical, tandem repetitive units of 121 amino acids in the central region of the mature Vaa product. Gain or loss of central repeats in vaa genes gives rise to distinct size-variant Vaa antigens in clonal populations of this organism. The N-terminal and repeat regions of Vaa contain highly conserved sequences, while the C-terminal region, implicated as the adherence-mediating module, is highly variable and divergent among different strains of this pathogen. Sequence variation in this region may underlie the strain-dependent binding of some monoclonal antibodies to Vaa products. The Vaa antigen is expressed in vivo during chronic, active arthritis associated with M. hominis infection and is highly immunogenic in the human host. Size variation and C-terminal antigenic divergence of Vaa could affect the adherence of M. hominis and evasion of antibody-mediated immunity, thereby contributing to the organism's adaptive capability in the human host. Variation in vaa genes reveals a distinct pattern of mutations generating mycoplasma surface variation.
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