ArticleInfection and immunity1996
Respiratory activity is essential for post-exponential-phase production of type 5 capsular polysaccharide by Staphylococcus aureus.
Article in Infection and immunity, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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Who cites it
14 citing papers in PubMed, 26 citations in OpenAlex.
- Iron restriction induces the small-colony variant phenotype inFrontiers in microbiology · 2022Article
- Host nutrient milieu drives an essential role for aspartate biosynthesis during invasiveProceedings of the National Academy of Sciences of the United States of America · 2020Article
- MsaB and CodY Interact To Regulate Staphylococcus aureus Capsule in a Nutrient-Dependent Manner.Journal of bacteriology · 2018Article
- Exposure of Methicillin-Resistant Staphylococcus aureus to Low Levels of the Antibacterial THAM-3ΦG Generates a Small Colony Drug-Resistant Phenotype.Scientific reports · 2018Article
- MsaB activates capsule production at the transcription level in Staphylococcus aureus.Microbiology (Reading, England) · 2016Article
- Influence of iron and aeration on Staphylococcus aureus growth, metabolism, and transcription.Journal of bacteriology · 2014Article
- Tricarboxylic acid cycle-dependent synthesis of Staphylococcus aureus Type 5 and 8 capsular polysaccharides.Journal of bacteriology · 2010Article
- Anaerobic gene expression in Staphylococcus aureus.Journal of bacteriology · 2007Article
- Complete and SOS-mediated response of Staphylococcus aureus to the antibiotic ciprofloxacin.Journal of bacteriology · 2007Article
- Staphylococcus aureus virulence factors identified by using a high-throughput Caenorhabditis elegans-killing model.Infection and immunity · 2005Article
- Staphylococcus aureus capsular polysaccharides.Clinical microbiology reviews · 2004Review
- Correlation of acetate catabolism and growth yield in Staphylococcus aureus: implications for host-pathogen interactions.Infection and immunity · 2003Article
- Adherence of Staphylococcus aureus to endothelial cells: influence of capsular polysaccharide, global regulator agr, and bacterial growth phase.Infection and immunity · 2000Article
- Production of toxic shock syndrome toxin 1 by Staphylococcus aureus requires both oxygen and carbon dioxide.Infection and immunity · 2000Article
Corrections and comments
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Capsule formation is believed to have a significant role in bacterial virulence. To examine the possible involvement of capsular polysaccharide (CP) from Staphylococcus aureus in the pathological mechanisms associated with staphylococcal infections, we investigated the influence of respiratory activity on type 5 CP production by S. aureus grown in the presence of various concentrations of dissolved oxygen or nitrate. The effects of several metabolic inhibitors (arsenite, cyanide, azide, trimethylamine N-oxide, 2-heptyl-4-hydroxyquinoline N-oxide, and 2,4-dinitrophenol) were also tested. The metabolism of the bacteria was estimated by measuring their reductive capacity and by monitoring the pH and concentrations of fermentation products. Type 5 CP was always produced by S. aureus during the exponential phase of growth under all culture conditions tested. In contrast, post-exponential-phase CP production appeared to be strictly dependent on the respiratory activity. Since post-exponential-phase CP production contributes at least two-thirds of the total CP obtained, the influence of S. aureus respiration on CP production might be of some importance in the process of infection.
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