ArticleImmunology1996
Oral aspirin and ibuprofen increase cytokine-induced synthesis of IL-1 beta and of tumour necrosis factor-alpha ex vivo.
Article in Immunology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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Who cites it
19 citing papers in PubMed, 61 citations in OpenAlex.
- Treatment With Acetylsalicylic Acid Reverses Endotoxin Tolerance in Humans In Vivo: A Randomized Placebo-Controlled Study.Critical care medicine · 2019Trial
- Physiologically relevant aspirin concentrations trigger immunostimulatory cytokine production by human leukocytes.PloS one · 2021Article
- Combined vitamin D, ibuprofen and glutamic acid decarboxylase-alum treatment in recent onset Type I diabetes: lessons from the DIABGAD randomized pilot trial.Future science OA · 2020Article
- Baltic amber teething necklaces: could succinic acid leaching from beads provide anti-inflammatory effects?BMC complementary and alternative medicine · 2019Article
- Neuroinflammation and Cytokines in Myalgic Encephalomyelitis/Chronic Fatigue Syndrome (ME/CFS): A Critical Review of Research Methods.Frontiers in neurology · 2018Review
- Plant Natural Product Puerarin Ameliorates Depressive Behaviors and Chronic Pain in Mice with Spared Nerve Injury (SNI).Molecular neurobiology · 2017Article
- Article
- Phenotyping drug polypharmacology via eicosanoid profiling of blood.Journal of lipid research · 2015Article
- Consistent inhibition of cyclooxygenase drives macrophages towards the inflammatory phenotype.PloS one · 2015Article
- Article
- Soluble TNF and IL-6 receptors: indicators of vascular health in women without cardiovascular disease.Vascular medicine (London, England) · 2013Article
- Aspirin: a review of its neurobiological properties and therapeutic potential for mental illness.BMC medicine · 2013Review
- The role of prophylactic ibuprofen and N-acetylcysteine on the level of cytokines in periapical exudates and the post-treatment pain.Daru : journal of Faculty of Pharmacy, Tehran University of Medical Sciences · 2012Article
- Mechanisms of non-opioid analgesics beyond cyclooxygenase enzyme inhibition.Current molecular pharmacology · 2009Review
- The effect of salicylates on insulin sensitivity.The Journal of clinical investigation · 2001Article
- Release of tumor necrosis factor-alpha and prostanoids in whole blood cultures after in vivo exposure to low-dose aspirin.Mediators of inflammation · 2001Article
- Acetaminophen selectively reduces glioma cell growth and increases radiosensitivity in culture.Journal of neuro-oncology · 2000Article
- Middle ear fluid cytokine and inflammatory cell kinetics in the chinchilla otitis media model.Infection and immunity · 1999Article
- The effect of renin-angiotensin system inhibitors on pro- and anti-inflammatory cytokine production.Immunology · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 2 institutions in 1 country.
Funding
Abstract
We investigated the effect of oral aspirin and ibuprofen on the ex vivo synthesis of interleukin-1 alpha (IL-1 alpha), IL-1 beta, IL-2, IL-6, tumour necrosis factor-alpha (TNF) and granulocyte-macrophage colony-stimulating factor (GM-CSF) by stimulated peripheral blood mononuclear cells (PBMC) from healthy volunteers. Seven volunteers took 325 mg of aspirin daily for 14 days. Three weeks after ending aspirin medication, ex vivo IL-1 beta and TNF synthesis induced by exogenous IL-1 alpha was elevated threefold compared to the pre-aspirin value (P = 0.01 and P = 0.005, respectively). Using lipopolysaccharide (LPS) as a stimulus, no influence of oral aspirin was observed. The increase in cytokine synthesis did not parallel decreased synthesis of prostaglandin E2 (PGE2). Seven weeks after discontinuation of aspirin, cytokine and PGE-2 production returned to pre-aspirin levels. Another seven volunteers took 200 mg of ibuprofen daily for 12 days. Again, there was no effect on LPS- or Staphylococcus epidermidis-induced cytokine synthesis. However, IL-1 alpha-induced synthesis of IL-1 beta was elevated to a mean individual increase of 538% (P < 0.001) and synthesis of TNF was elevated to 270% (P < 0.001) at the end of ibuprofen medication and 2 weeks after discontinuation of ibuprofen. There were parallel increases in PGE2 and both returned to their pre-ibuprofen levels 5 weeks after stopping. Although inhibitors of cyclo-oxygenase blunt PGE2-mediated symptoms such as fever and pain, we conclude that short term use of either aspirin or ibuprofen results in a 'rebound' increase in cytokine-induced cytokine synthesis that is not observed in LPS-induced cytokines.
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