ArticleThe EMBO journal1996
p75(NGFR) and TrkA receptors collaborate to rapidly activate a p75(NGFR)-associated protein kinase.
Article in The EMBO journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
What it found
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Who cites it
15 citing papers in PubMed, 53 citations in OpenAlex.
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- BMP9 (bone morphogenetic protein 9) induces NGF as an autocrine/paracrine cholinergic trophic factor in developing basal forebrain neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2010Article
- High-resolution fractionation of signaling endosomes containing different receptors.Traffic (Copenhagen, Denmark) · 2009Article
- Pathophysiological mechanisms for actions of the neurotrophins.Brain pathology (Zurich, Switzerland) · 2006Review
- Signaling of neuronal cell death by the p75NTR neurotrophin receptor.Molecular neurobiology · 1999Review
- Depolarization and cAMP elevation rapidly recruit TrkB to the plasma membrane of CNS neurons.Neuron · 1998Article
- Nerve growth factor abrogates the tumorigenicity of human small cell lung cancer cell lines.Proceedings of the National Academy of Sciences of the United States of America · 1998Article
- A signaling organelle containing the nerve growth factor-activated receptor tyrosine kinase, TrkA.Proceedings of the National Academy of Sciences of the United States of America · 1997Article
- Optimal nerve growth factor trophic signals mediated by synergy of TrkA and p75 receptor-specific ligands.The Journal of neuroscience : the official journal of the Society for Neuroscience · 1997Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
The role of the low affinity nerve growth factor receptor (p75(NGFR)) in NGF-mediated signaling is not yet understood. Here we show by co-immunoprecipitation that NGF activates a protein kinase that is directly associated with p75(NGFR) in dorsal root ganglion (DRG) cells and PC12 cells in culture. Two proteins of 120 and 104 kDa constitute the majority of this activity. In PC12 cells, TrkA activation was necessary to elicit p75(NGFR)-associated kinase activity. Although NGF binding to p75(NGFR) was not necessary for kinase activation, it accelerated the activation of the kinase at low NGF concentrations. Deletion analysis showed that a 43 amino acid region in the cytoplasmic domain of p75(NGFR) was responsible for this effect. These findings show that p75(NGFR) accelerates TrkA-mediated signaling and, in addition, demonstrate that p75NGFR and TrkA collaborate to activate a previously undescribed p75(NGFR)-associated protein kinase.
Indexed as
Identifiers
8698038PMC451900W143657778What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.