ArticleHeart (British Cardiac Society)1996
After-effects of exercise on haemodynamics and muscle sympathetic nerve activity in young patients with dilated cardiomyopathy.
Article in Heart (British Cardiac Society), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers, 1 of them a synthesis that pooled it.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
6 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Acute Effects of Exercise on Blood Pressure: A Meta-Analytic Investigation.Arquivos brasileiros de cardiologia · 2016Pooled it
- Training History, Cardiac Autonomic Recovery from Submaximal Exercise and Associated Performance in Recreational Runners.International journal of environmental research and public health · 2022Article
- Exercise training normalizes enhanced glutamate-mediated sympathetic activation from the PVN in heart failure.American journal of physiology. Regulatory, integrative and comparative physiology · 2008Article
- Muscle sympathetic nerve activity and ventilation during exercise in subjects with and without chronic heart failure.The Canadian journal of cardiology · 2008Article
- Increased cardiac sympathetic nerve activity in heart failure is not due to desensitization of the arterial baroreflex.American journal of physiology. Heart and circulatory physiology · 2007Article
- Potential causes, mechanisms, and implications of post exercise hypotension.Journal of human hypertension · 2002Review
Corrections and comments
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Authors and funding
2 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine the after-effects on sympathetic nerve activity and calf and systemic haemodynamics of symptom-limited exercise in young patients with dilated cardiomyopathy. PATIENTS: 14 young patients with dilated cardiomyopathy (mean (SEM) age 35 (2) yr) and 17 healthy controls (age 29 (2) yr).
methodsBlood pressure, muscle sympathetic nerve activity, calf blood flow, plasma noradrenaline, and stroke volume were recorded during baseline rest and an hour after symptom-limited treadmill exercise (up to 45 min) at 70% of resting heart rate reserve.
resultsBefore exercise, sympathetic nerve activity (45 (6) v 21 (2) bursts.min-1; P = 0.001) and calf vascular resistance (55 (5) v 31 (3) units; P < 0.0005) were higher in the dilated cardiomyopathy group, and there was a significant correlation between these two variables (r = +0.64; P < 0.001). Patients with ventricular dysfunction exercised for 31 (3) min. In both groups there were significant and similar reductions in diastolic blood pressure, total peripheral resistance, and calf vascular resistance after exercise. Sympathetic nerve activity and plasma noradrenaline were unchanged and there was no longer any relation between muscle sympathetic nerve activity and calf vascular resistance. Cardiac output increased in both groups but, in contrast to healthy controls, mean values for systolic blood pressure and stroke volume (P < 0.005) did not decrease in the cardiomyopathy group. For similar reductions in total peripheral resistance, there were two to three fold greater increases in stroke volume after exercise in patients with left ventricular dysfunction (P < 0.03). There was no relation between exercise duration and the magnitude of these after-effects of exercise in these patients.
conclusionsIn young patients with dilated cardiomyopathy the haemodynamic after-effects of submaximal symptom-limited exercise resemble responses to pharmacological afterload reduction but are not accompanied by reflex sympathetic activation. Sustained calf and systemic vasodilation after exercise were not attenuated, as compared with healthy controls. These cardiac, peripheral, and sympathoneural after-effects provide further support for exercise training as a non-pharmacological adjunct to the management of chronic stable heart failure.
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