ArticleHeart (British Cardiac Society)1996
Prospective relations between Helicobacter pylori infection, coronary heart disease, and stroke in middle aged men.
Article in Heart (British Cardiac Society), 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 48 papers, 7 of them syntheses that pooled it.
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Who cites it
48 citing papers in PubMed, 7 syntheses or guidelines pooled it, 203 citations in OpenAlex.
- Pooled it
- An Updated Meta-Analysis of the Relationship BetweenFrontiers in cardiovascular medicine · 2022Pooled it
- Association between Helicobacter Pylori infection and stroke: a meta-analysis of 273,135 patients.Journal of neurology · 2021Pooled it
- Antibiotics for secondary prevention of coronary heart disease.The Cochrane database of systematic reviews · 2021Pooled it
- Effect of Helicobacter pylori infection on the risk of acute coronary syndrome: A systematic review and meta-analysis.Medicine · 2019Pooled it
- Is there an association between Helicobacter pylori infection and coronary heart disease?European journal of epidemiology · 1999Pooled it
- Risk factors for coronary heart disease and infection with Helicobacter pylori: meta-analysis of 18 studies.BMJ (Clinical research ed.) · 1998Pooled it
- The association between current Helicobacter pylori infection and coronary artery disease.The Korean journal of internal medicine · 2007Trial
- Cardiovascular and Neurological Diseases and Association with Helicobacter Pylori Infection-An Overview.Diagnostics (Basel, Switzerland) · 2024Review
- Risk of Ischemic Stroke in Relation toGut and liver · 2024Observational
- Association betweenFrontiers in endocrinology · 2023Article
- The effect ofArchives of medical science : AMS · 2022Review
- Genetic Analyses of Common Infections in the Avon Longitudinal Study of Parents and Children Cohort.Frontiers in immunology · 2021Article
- H. pylori infection and extra-gastroduodenal diseases.Journal of biomedical science · 2018Review
- Review
- Association between Bacterial Infection and Peripheral Vascular Disease: A Review.The International journal of angiology : official publication of the International College of Angiology, Inc · 2016Review
- Association between Helicobacter pylori Infection and Cerebral Small Vessel Disease.Korean journal of family medicine · 2015Article
- Role of Helicobacter pylori infection in pathogenesis of atherosclerosis.World journal of cardiology · 2015Review
- Helicobacter pylori infection and the risk of acute coronary syndrome: a nationwide retrospective cohort study.European journal of clinical microbiology & infectious diseases : official publication of the European Society of Clinical Microbiology · 2015Article
- Clinical significance of Helicobacter pylori infection in patients with acute coronary syndromes: an overview of current evidence.Clinical research in cardiology : official journal of the German Cardiac Society · 2014Review
Corrections and comments
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Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectiveTo determine whether Helicobacter pylori, a chronic bacterial infection often acquired in childhood, is associated with increased risk of coronary heart disease and stroke later in life.
designNested case-control study.
settingProspective study of cardiovascular disease in men aged 40-59 years at entry (1978-1980) in 24 British towns. SUBJECTS: 135 cases of myocardial infarction and 137 cases of stroke occurring before December 1991; 136 controls were identified, frequency matched to cases by town and age group.
methodsSerum samples stored at entry were analysed by an enzyme linked immunosorbent assay for the presence of H pylori specific IgG antibodies.
results95 of the myocardial infarction cases (70%) and 93 (68%) of the stroke cases were seropositive for H pylori compared with 78 (57%) of the controls (odds ratio for myocardial infarction 1.77, 95% confidence interval (CI) 1.06 to 2.95, P = 0.03; odds ratio for stroke 1.57, 95% CI 0.95 to 2.60, P = 0.07). Helicobacter pylori infection was associated with manual social class, residence in Northern England or Scotland, cigarette smoking, higher systolic pressure and blood glucose, and a lower height-standardised forced expiratory volume in one second. Adjustment for these factors attenuated the relation between H pylori and myocardial infarction (odds ratio = 1.31, 95% CI 0.70 to 2.43, P = 0.40) and effectively abolished the relation with stroke (odds ratio = 0.96, 0.46 to 2.02, P = 0.92). The relation between helicobacter infection and fatal myocardial infarction was slightly stronger (odds ratio 2.41, 95% CI 1.13 to 5.12) but was also markedly attenuated after adjustment (1.56, 95% CI 0.68 to 3.61).
conclusionIn this prospective study the association between Helicobacter pylori infection and increased risk of myocardial infarction and stroke was substantially confounded by the relation between this infection, adult social class, and major cardiovascular risk factors.
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