ArticleBritish journal of cancer1996
Alternatively spliced variants of the cell adhesion molecule CD44 and tumour progression in colorectal cancer.
Article in British journal of cancer, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 32 papers, 1 of them a synthesis that pooled it.
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Who cites it
32 citing papers in PubMed, 1 synthesis or guideline pooled it, 99 citations in OpenAlex.
- The Prognostic and Clinical Value of CD44 in Colorectal Cancer: A Meta-Analysis.Frontiers in oncology · 2019Pooled it
- Expression and clinical significance of CD44V5 and CD44V6 in resectable colorectal cancer.Journal of cancer research and clinical oncology · 2004Trial
- Cell Surface Markers of Mesenchymal Stem Cells: Current Knowledge and Advances in Characterization Technologies.Life (Basel, Switzerland) · 2025Review
- Less demand on stem cell marker-positive cancer cells may characterize metastasis of colon cancer.PloS one · 2023Article
- Transcriptome analysis of clock disrupted cancer cells reveals differential alternative splicing of cancer hallmarks genes.NPJ systems biology and applications · 2022Article
- Alternative Splicing: Expanding the Landscape of Cancer Biomarkers and Therapeutics.International journal of molecular sciences · 2020Review
- Cancer stem cell-associated miRNAs serve as prognostic biomarkers in colorectal cancer.JCI insight · 2019Article
- Association of Two CD44 Polymorphisms with Clinical Outcomes of Gastric Cancer PatientsAsian Pacific journal of cancer prevention : APJCP · 2018Article
- CD44v6 down-regulation is an independent prognostic factor for poor outcome of colorectal carcinoma.International journal of clinical and experimental pathology · 2015Article
- Alternative splicing for diseases, cancers, drugs, and databases.TheScientificWorldJournal · 2013Review
- Characteristics of CD44 alternative splice pattern in the course of human colorectal adenocarcinoma progression.Molecular cancer · 2012Article
- Germline polymorphisms in genes involved in the CD44 signaling pathway are associated with clinical outcome in localized gastric adenocarcinoma.International journal of cancer · 2011Article
- New-generation taxoid SB-T-1214 inhibits stem cell-related gene expression in 3D cancer spheroids induced by purified colon tumor-initiating cells.Molecular cancer · 2010Article
- Rac1 signaling modulates BCL-6-mediated repression of gene transcription.Molecular and cellular biology · 2009Article
- Comparison of cyclooxygenase-2 and CD44 mRNA expression in colorectal cancer and its relevance for prognosis.Virchows Archiv : an international journal of pathology · 2009Article
- The beta-catenin/TCF4 pathway modifies alternative splicing through modulation of SRp20 expression.RNA (New York, N.Y.) · 2008Article
- Epithelial hyaluronic acid and CD44v6 are mutually involved in invasion of colorectal adenocarcinomas and linked to patient prognosis.Virchows Archiv : an international journal of pathology · 2004Article
- Significance of immunohistochemical over-expression of CD44v6 as an indicator of malignant potential in esophageal squamous cell carcinoma.Journal of cancer research and clinical oncology · 2004Article
- Expression of proliferating cell nuclear antigen and CD44 variant exon 6 in primary tumors and corresponding lymph node metastases of colorectal carcinoma with Dukes' stage C or D.World journal of gastroenterology · 2003Article
- Butyrate down-regulates CD44 transcription and liver colonisation in a highly metastatic human colon carcinoma cell line.British journal of cancer · 2002Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
6 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Increased expression of alternatively spliced variants of the CD44 family of cell adhesion molecules has been associated with tumour metastasis. In the present study, expression of alternatively spliced variants of CD44 and their cellular distribution have been investigated in human colonic tumours and in the corresponding normal mucosa, in addition to benign adenomatous polyps. The expression of CD44 alternatively spliced variants has been correlated with tumour progression according to Dukes' histological stage. CD44 variant expression was determined by immunohistochemisty using monoclonal antibodies directed against specific CD44 variant domains together with RT-PCR analysis of CD44 variant mRNA expression in the same tissue specimens. We demonstrate that as well as being expressed in colonic tumour cells, the full range of CD44 variants, CD44v2-v10, are widely expressed in normal colonic crypt epithelium, predominantly in the crypt base. CD44v6, the epitope which is most commonly associated with tumour progression and metastasis, was not only expressed by many benign colonic tumours, but was expressed as frequently in normal basal crypt epithelium as in malignant colonic tumour cells, and surprisingly, was even absent from some metastatic colorectal tumours. Expression of none of the CD44 variant epitopes was found to be positively correlated with tumour progression or with colorectal tumour metastasis to the liver, results which are inconsistent with a role for CD44 variants as indicators of colonic cancer progression.
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