ArticleCalcified tissue international1996
Aromatization of androgens is important for skeletal maintenance of aged male rats.
Article in Calcified tissue international, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 11 papers.
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Who cites it
11 citing papers in PubMed, 90 citations in OpenAlex.
- Effect of aromatase inhibition on bone metabolism in elderly hypogonadal men.Osteoporosis international : a journal established as result of cooperation between the European Foundation for Osteoporosis and the National Osteoporosis Foundation of the USA · 2005Trial
- Relative contributions of testosterone and estrogen in regulating bone resorption and formation in normal elderly men.The Journal of clinical investigation · 2000Trial
- Effect of hydroalcoholic extract of flaxseed on bone mineral density in Wistar rats using digital radiography.Caspian journal of internal medicine · 2020Article
- Pyrroloquinoline quinone prevents testosterone deficiency-induced osteoporosis by stimulating osteoblastic bone formation and inhibiting osteoclastic bone resorption.American journal of translational research · 2017Article
- Influence of aromatase inhibition on the bone-protective effects of testosterone.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2014Article
- The effects of sex steroids on thyroid C cells and trabecular bone structure in the rat model of male osteoporosis.Journal of anatomy · 2013Article
- Combined Effects of Eurycoma longifolia and Testosterone on Androgen-Deficient Osteoporosis in a Male Rat Model.Evidence-based complementary and alternative medicine : eCAM · 2012Article
- Osteoporosis in patients with subclinical hypothyroidism treated with thyroid hormone.Clinical cases in mineral and bone metabolism : the official journal of the Italian Society of Osteoporosis, Mineral Metabolism, and Skeletal Diseases · 2011Article
- Estrogen receptor specificity in the regulation of skeletal growth and maturation in male mice.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The bone-building action of the parathyroid hormone: implications for the treatment of osteoporosis.Drugs & aging · 1999Review
- Osteoporosis in men. New insights into aetiology, pathogenesis, prevention and management.Drugs & aging · 1998Review
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A nonsteroidal aromatase inhibitor vorozole (VOR) was administered to aged (12 months old) male Wistar rats and its effect was compared with the effect of androgen deficiency. The rats were either sham-operated (SHAM) or orchidectomized (ORCH) and treated with or without VOR. Thus, four experimental groups were created (SHAM, ORCH, SHAM + VOR, ORCH + VOR). The follow-up period was 4 months. At the end of the experimental period, bone mineral density (BMD) of the first four lumbar vertebrae and right femur was measured ex vivo with dual-energy X-ray absorptiometry, bone formation was evaluated by serum osteocalcin, and bone resorption by urinary excretion of (deoxy)pyridinoline. Orchidectomy increased bone resorption 2- to 3-fold whereas bone formation was only slightly increased. Treatment of intact male rats with VOR also increased bone resorption (+30% increase) whereas bone formation was not increased in this SHAM + VOR group. Their BMD was 7% lower in the femur (P < 0.01) and 6% lower in the lumbar vertebrae (P < 0.01) compared with the SHAM group that had not received VOR. Moreover, this decrease of bone mineral density was not significantly different from the expected decrease of bone density observed in the ORCH groups (6-10%). This was also reflected by a decrease of calcium content of the first four lumbar vertebrae of 15% (P < 0.001) in the SHAM + VOR group and 9-14% (P < 0.05) in the ORCH groups compared with the SHAM group, respectively. These data therefore suggest that inhibition of aromatization of androgens into estrogens increases bone resorption and bone loss similar to that observed after complete removal of androgens. Aromatization of androgens into estrogens may therefore, at least partly, explain the effects of androgens on skeletal maintenance.
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