ArticleThe Biochemical journal1996
The variable subunit associated with protein phosphatase 2A0 defines a novel multimember family of regulatory subunits.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 23 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
23 citing papers in PubMed, 76 citations in OpenAlex.
- Article
- Supramolecular assemblies and localized regulation of voltage-gated ion channels.Physiological reviews · 2009Review
- Identification of a novel conserved mixed-isoform B56 regulatory subunit and spatiotemporal regulation of protein phosphatase 2A during Xenopus laevis development.BMC developmental biology · 2007Article
- Protein kinase A activates protein phosphatase 2A by phosphorylation of the B56delta subunit.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
- An inactive protein phosphatase 2A population is associated with methylesterase and can be re-activated by the phosphotyrosyl phosphatase activator.The Biochemical journal · 2004Article
- The role of serine/threonine protein phosphatases in exocytosis.The Biochemical journal · 2003Review
- Molecular characterization and evolution of the protein phosphatase 2A B' regulatory subunit family in plants.Plant physiology · 2002Article
- Review
- Phosphorylation-dependent regulation of ryanodine receptors: a novel role for leucine/isoleucine zippers.The Journal of cell biology · 2001Article
- Protein phosphatase 2A: a highly regulated family of serine/threonine phosphatases implicated in cell growth and signalling.The Biochemical journal · 2001Review
- Amplification of dopaminergic signaling by a positive feedback loop.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- Carboxyl methylation regulates phosphoprotein phosphatase 2A by controlling the association of regulatory B subunits.The EMBO journal · 2000Article
- Carboxyl methylation of the phosphoprotein phosphatase 2A catalytic subunit promotes its functional association with regulatory subunits in vivo.The EMBO journal · 2000Article
- Induction of p53-independent apoptosis by the adenovirus E4orf4 protein requires binding to the Balpha subunit of protein phosphatase 2A.Journal of virology · 2000Article
- Article
- Phosphorylation and activation of phosphodiesterase type 3B (PDE3B) in adipocytes in response to serine/threonine phosphatase inhibitors: deactivation of PDE3B in vitro by protein phosphatase type 2A.The Biochemical journal · 1999Article
- Vimentin dephosphorylation by protein phosphatase 2A is modulated by the targeting subunit B55.Molecular biology of the cell · 1999Article
- Methylated C-terminal leucine residue of PP2A catalytic subunit is important for binding of regulatory Balpha subunit.The Biochemical journal · 1999Article
- Functional interaction between a novel protein phosphatase 2A regulatory subunit, PR59, and the retinoblastoma-related p107 protein.Oncogene · 1999Article
- Linkage mapping of the Bra, Brb and Brg genes for rat protein phosphatase 2A 55 kDa B-regulatory subunit isotypes.Japanese journal of cancer research : Gann · 1998Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
8 authors at 2 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Two protein phosphatase 2A (PP2A) holoenzymes were isolated from rabbit skeletal muscle containing, in addition to the catalytic and PR65 regulatory subunits, proteins of apparent molecular masses of 61 and 56 kDa respectively. Both holoenzymes displayed low basal phosphorylase phosphatase activity, which could be stimulated by protamine to an extent similar to that of previously characterized PP2A holoenzymes. Protein micro-sequencing of tryptic peptides derived from the 61 kDa protein, termed PR61, yielded 117 residues of amino acid sequence. Molecular cloning by enrichment of specific mRNAs, followed by reverse transcription-PCR and cDNA library screening, revealed that this protein exists in multiple isoforms encoded by at least three genes, one of which gives rise to several splicing variants. Comparisons of these sequences with the available databases identified one more human gene and predicted another based on a rabbit cDNA-derived sequence, thus bringing the number of genes encoding PR61 family members to five. Peptide sequences derived from PR61 corresponded to the deduced amino acid sequences of either alpha or beta isoforms, indicating that the purified PP2A preparation was a mixture of at least two trimers. In contrast, the 56 kDa subunit (termed PR56) seems to correspond to the epsilon isoform of PR61. Several regulatory subunits of PP2A belonging to the PR61 family contain consensus sequences for nuclear localization and might therefore target PP2A to nuclear substrates.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.