ArticleThe Biochemical journal1996
Evidence that filaggrin is a component of cornified cell envelopes in human plantar epidermis.
Article in The Biochemical journal, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
19 citing papers in PubMed, 51 citations in OpenAlex.
- Epithelial Barrier Dysfunction in Atopic Dermatitis, Allergic Contact Dermatitis, and Chronic Spontaneous Urticaria and its Therapeutic Implications.Current allergy and asthma reports · 2026Review
- Evolutionary Balancing of Genetic Consequence and Innovation in Mammals Through Variable Number Tandem Repeats.Genome biology and evolution · 2026Review
- Revisiting the Roles of Filaggrin in Atopic Dermatitis.International journal of molecular sciences · 2022Review
- Corneal epithelium in keratoconus underexpresses active NRF2 and a subset of oxidative stress-related genes.PloS one · 2022Article
- Five Functional Aspects of the Epidermal Barrier.International journal of molecular sciences · 2021Review
- Cracking the Skin Barrier: Liquid-Liquid Phase Separation Shines under the Skin.JID innovations : skin science from molecules to population health · 2021Review
- Review
- Refined Immunochemical Characterization in Healthy Dog Skin of the Epidermal Cornification Proteins, Filaggrin, and Corneodesmosin.The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society · 2019Article
- Patterns of host gene expression associated with harboring a foregut microbial community.BMC genomics · 2017Article
- Lowering relative humidity level increases epidermal protein deimination and drives human filaggrin breakdown.Journal of dermatological science · 2017Article
- Atopic Dermatitis Susceptibility Variants in Filaggrin Hitchhike Hornerin Selective Sweep.Genome biology and evolution · 2016Article
- Filaggrin breakdown products determine corneocyte conformation in patients with atopic dermatitis.The Journal of allergy and clinical immunology · 2015Article
- Epidermal barrier disorders and corneodesmosome defects.Cell and tissue research · 2015Review
- Filaggrin is a predominant member of the denaturation-resistant nickel-binding proteome of human epidermis.The Journal of investigative dermatology · 2014Article
- Urea uptake enhances barrier function and antimicrobial defense in humans by regulating epidermal gene expression.The Journal of investigative dermatology · 2012Article
- Filaggrin genotype in ichthyosis vulgaris predicts abnormalities in epidermal structure and function.The American journal of pathology · 2011Article
- Delineation of matriptase protein expression by enzymatic gene trapping suggests diverging roles in barrier function, hair formation, and squamous cell carcinogenesis.The American journal of pathology · 2006Article
- Loss of proteolytically processed filaggrin caused by epidermal deletion of Matriptase/MT-SP1.The Journal of cell biology · 2003Article
- Differentially expressed late constituents of the epidermal cornified envelope.Proceedings of the National Academy of Sciences of the United States of America · 2001Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Cornified cell envelope (CE) is generated during the late stages of epidermal differentiation and is made up of proteins covalently linked together by transglutaminases. To determine whether filaggrin is a component of this structure in humans, we analysed highly purified CE from plantar stratum corneum. An immunoelectron microscopy analysis showed specific binding of four different anti-(pro)filaggrin monoclonal antibodies to the surface of the CE, proved previously to be free of non-covalently linked proteins. Moreover, the anti-filaggrin activity of one of the antibodies was absorbed by preincubation with the plantar CE, as determined by ELISA. Convincingly, fragments of CE produced by proteolytic digestion of the structures were stained by this antibody on immunoblots. These data provide direct evidence that filaggrin is a component of CE purified from human plantar stratum corneum. Cross-linking between CE and the filaggrin-containing fibrous matrix may enhance the structural cohesion of the corneocytes and thus the resistance of the stratum corneum.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.