ReviewAnatomy and embryology1996
Morphology of interstitial cells in the healthy kidney.
Review in Anatomy and embryology, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 44 papers.
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Who cites it
44 citing papers in PubMed, 121 citations in OpenAlex.
- Defining the molecular fingerprint of bladder and kidney fibroblasts.American journal of physiology. Renal physiology · 2023Review
- Obstructive nephropathy and molecular pathophysiology of renal interstitial fibrosis.Physiological reviews · 2023Review
- Effects of recombinant human soluble thrombomodulin on neutrophil extracellular traps in the kidney of a mouse model of endotoxin shock.Fujita medical journal · 2023Article
- Renal Proximal Tubular Cells: A New Site for Targeted Delivery Therapy of Diabetic Kidney Disease.Pharmaceuticals (Basel, Switzerland) · 2022Review
- SIRT1 attenuates renal fibrosis by repressing HIF-2α.Cell death discovery · 2021Article
- Role of Nanotechnology and Their Perspectives in the Treatment of Kidney Diseases.Frontiers in genetics · 2021Review
- Emerging Roles of Long Non-Coding RNAs in Renal Fibrosis.Life (Basel, Switzerland) · 2020Review
- Furosemide stress test and interstitial fibrosis in kidney biopsies in chronic kidney disease.BMC nephrology · 2020Article
- Mice with a Brd4 Mutation Represent a New Model of Nephrocalcinosis.Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research · 2019Article
- Article
- Renal Interstitial Platelet-Derived Growth Factor Receptor-Journal of the American Society of Nephrology : JASN · 2018Article
- Endocrine functions of the renal interstitium.Pflugers Archiv : European journal of physiology · 2017Review
- Highly suggestive preliminary evidence that the renal interstitium contracts in vivo.Physiological reports · 2017Article
- Tissue-Resident Macrophages in Fungal Infections.Frontiers in immunology · 2017Review
- Article
- Bone Marrow CD11c+ Cell-Derived Amphiregulin Promotes Pulmonary Fibrosis.Journal of immunology (Baltimore, Md. : 1950) · 2016Article
- Dendritic Cells in Kidney Transplant Biopsy Samples Are Associated with T Cell Infiltration and Poor Allograft Survival.Journal of the American Society of Nephrology : JASN · 2015Article
- Dendritic Cells and Macrophages: Sentinels in the Kidney.Clinical journal of the American Society of Nephrology : CJASN · 2015Review
- Renal fibrosis is not reduced by blocking transforming growth factor-β signaling in matrix-producing interstitial cells.Kidney international · 2015Article
- Renal F4/80+ CD11c+ mononuclear phagocytes display phenotypic and functional characteristics of macrophages in health and in adriamycin nephropathy.Journal of the American Society of Nephrology : JASN · 2015Article
Corrections and comments
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Authors and funding
4 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Renal interstitial cells play an important role in renal function and renal diseases. We describe the morphology of renal interstitial cells in the healthy kidney. We distinguish within the renal interstitium (1) renal fibroblasts and (2) cells of the immune system. Fibroblasts are in the majority and constitute the scaffold of the kidney; they are interconnected by junctions, and are attached to tubules and vessels. Although the phenotype of fibroblasts shows some variation depending on their location in the kidney and on their functional stage, their recognition as fibroblasts is possible on account of structural features. Among the cell types of the second group, antigen-presenting dendritic cells are the most abundant in in the peritubular interstitial spaces of healthy kidneys. Their incidence is highest in the inner stripe of the outer medulla. They share some morphological features with fibroblasts but lack others--junctional complexes, morphologically defined connections with tubules and vessels, and the prominent layer of actin filaments under the plasma membrane--that are characteristic for fibroblasts. Dendritic cells in healthy kidneys are morphologically different from macrophages, which are characterized by abundant primary and secondary lysosomes. In healthy kidneys macrophages are restricted to the connective tissue of the renal capsule and the pelvic wall, and to the periarterial connective tissue. Lymphocytes are rare in healthy kidneys. The distinction of cell types by morphology is supported by differences of membrane proteins. Among all interstitial cells in the renal cortex, fibroblasts alone exhibit ecto-5'-nucleotidase. Dendritic cells constitutively have a high abundance of MHC class II protein. Both proteins are mutually exclusive. Rat macrophages display the membrane antigen ED 2 and lymphocytes exhibit specific surface antigens, depending on their type and functional stage, e.g., CD4 or CD8.
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