ArticleProceedings of the National Academy of Sciences of the United States of America1996
A chromosomal locus required for copper resistance, competitive fitness, and cytochrome c biogenesis in Pseudomonas fluorescens.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.
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Who cites it
20 citing papers in PubMed, 56 citations in OpenAlex.
- Genome-wide identification of tolerance mechanisms toward p-coumaric acid in Pseudomonas putida.Biotechnology and bioengineering · 2018Article
- The Herbaspirillum seropedicae SmR1 Fnr orthologs controls the cytochrome composition of the electron transport chain.Scientific reports · 2013Article
- Article
- Missense mutations in cytochrome c maturation genes provide new insights into Rhodobacter capsulatus cbb3-type cytochrome c oxidase biogenesis.Journal of bacteriology · 2013Article
- Improved antibiotic resistance gene cassette for marker exchange mutagenesis in Ralstonia solanacearum and Burkholderia species.Journal of microbiology (Seoul, Korea) · 2011Article
- Multiple metal tolerance and biosorption of cadmium by Candida tropicalis isolated from industrial effluents: glutathione as detoxifying agent.Environmental monitoring and assessment · 2011Article
- Indole-3-acetic acid biosynthesis is deficient in Gluconacetobacter diazotrophicus strains with mutations in cytochrome c biogenesis genes.Journal of bacteriology · 2004Article
- Features of Rhodobacter sphaeroides CcmFH.Journal of bacteriology · 2003Article
- The cytochrome c maturation locus of Legionella pneumophila promotes iron assimilation and intracellular infection and contains a strain-specific insertion sequence element.Infection and immunity · 2002Article
- Copper-resistant bacteria from industrial effluents and their role in remediation of heavy metals in wastewater.Folia microbiologica · 2002Article
- Chromosomal locus for cadmium resistance in Pseudomonas putida consisting of a cadmium-transporting ATPase and a MerR family response regulator.Applied and environmental microbiology · 2001Article
- Genetic and biochemical characterization of the pathway in Pantoea citrea leading to pink disease of pineapple.Journal of bacteriology · 2000Article
- Heme transfer to the heme chaperone CcmE during cytochrome c maturation requires the CcmC protein, which may function independently of the ABC-transporter CcmAB.Proceedings of the National Academy of Sciences of the United States of America · 1999Article
- The cytochrome c maturation operon is involved in manganese oxidation in Pseudomonas putida GB-1.Applied and environmental microbiology · 1998Article
- c-type cytochromes and manganese oxidation in Pseudomonas putida MnB1.Applied and environmental microbiology · 1998Article
- Transcriptional control and essential roles of the Escherichia coli ccm gene products in formate-dependent nitrite reduction and cytochrome c synthesis.The Biochemical journal · 1998Article
- The active-site cysteines of the periplasmic thioredoxin-like protein CcmG of Escherichia coli are important but not essential for cytochrome c maturation in vivo.Journal of bacteriology · 1998Article
- Cell biology and molecular basis of denitrification.Microbiology and molecular biology reviews : MMBR · 1997Review
- Biogenesis of respiratory cytochromes in bacteria.Microbiology and molecular biology reviews : MMBR · 1997Review
- A Salmonella typhimurium genetic locus which confers copper tolerance on copper-sensitive mutants of Escherichia coli.Journal of bacteriology · 1997Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
A chromosomal locus required for copper resistance and competitive fitness was cloned from a strain of Pseudomonas fluorescens isolated from copper-contaminated agricultural soil. Sequence analysis of this locus revealed six open reading frames with homology to genes involved in cytochrome c biogenesis in other bacteria, helC, cycJ, cycK, tipB, cycL, and cycH, with the closest similarity being to the aeg-46.5(yej) region of the Escherichia coli chromosome. The proposed functions of these genes in other bacteria include the binding, transport, and coupling of heme to apocytochrome c in the periplasm of these Gram-negative bacteria. Putative heme-binding motifs were present in the predicted products of cycK and cycL, and TipB contained a putative disulfide oxidoreductase active site proposed to maintain the heme-binding site of the apocytochrome in a reduced state for ligation of heme. Tn3-gus mutagenesis showed that expression of the genes was constitutive but enhanced by copper, and confirmed that the genes function both in copper resistance and production of active cytochrome c. However, two mutants in cycH were copper-sensitive and oxidase-positive, suggesting that the functions of these genes, rather than cytochrome c oxidase itself, were required for resistance to copper.
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