ArticleProceedings of the National Academy of Sciences of the United States of America1996
Mini-chromosomes derived from the human Y chromosome by telomere directed chromosome breakage.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers.
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Who cites it
40 citing papers in PubMed.
- Synthetic rewriting technologies in mammalian cells.Nature communications · 2026Review
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- Assembly of Multiple Full-Size Genes or Genomic DNA Fragments on Human Artificial Chromosomes Using the Iterative Integration System.Current protocols · 2021Article
- Targeting chromosome trisomy for chromosome editing.Scientific reports · 2021Article
- Gene expressing human artificial chromosome vectors: Advantages and challenges for gene therapy.Experimental cell research · 2020Review
- Article
- Human Artificial Chromosome with Regulated Centromere: A Tool for Genome and Cancer Studies.ACS synthetic biology · 2018Review
- Review
- De novo formed satellite DNA-based mammalian artificial chromosomes and their possible applications.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- A pathway from chromosome transfer to engineering resulting in human and mouse artificial chromosomes for a variety of applications to bio-medical challenges.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Engineered minichromosomes in plants.Chromosome research : an international journal on the molecular, supramolecular and evolutionary aspects of chromosome biology · 2015Review
- Bi-HAC vector system toward gene and cell therapy.ACS synthetic biology · 2014Article
- Article
- A new generation of human artificial chromosomes for functional genomics and gene therapy.Cellular and molecular life sciences : CMLS · 2013Review
- Human artificial chromosomes for gene delivery and the development of animal models.Molecular therapy : the journal of the American Society of Gene Therapy · 2011Review
- De novo assembly of potential linear artificial chromosome constructs capped with expansive telomeric repeats.Plant methods · 2011Article
- Refined human artificial chromosome vectors for gene therapy and animal transgenesis.Gene therapy · 2011Article
- Artificial chromosome formation in maize (Zea mays L.).Chromosoma · 2009Article
- Minichromosome analysis of chromosome pairing, disjunction, and sister chromatid cohesion in maize.The Plant cell · 2007Article
- Construction and behavior of engineered minichromosomes in maize.Proceedings of the National Academy of Sciences of the United States of America · 2007Article
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4 authors.
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Abstract
We have used telomeric DNA to break two acrocentric derivatives of the human Y chromosome into mini-chromosomes that are small enough to be size- fractionated by pulsed-field gel electrophoresis. One of the mini-chromosomes is about 7 Mb in size and sequence-tagged site analysis of this molecule suggests that it corresponds to a simple truncation of the short arm of the Y chromosome. Five of the mini-chromosomes are derived from the long arm, are all rearranged by more than a simple truncation, and range in size from 4.0 Mb to 9 Mb. We have studied the mitotic stabilities of these mini-chromosomes and shown that they are stably maintained by cells proliferating in culture for about 100 cell divisions.
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