ArticleProceedings of the National Academy of Sciences of the United States of America1996
Evolutionary changes in the expression pattern of a developmentally essential gene in three Drosophila species.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 15 papers.
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Who cites it
15 citing papers in PubMed, 43 citations in OpenAlex.
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- Population-Specific Genetic and Expression Differentiation in Europeans.Genome biology and evolution · 2020Article
- A quantitative framework for characterizing the evolutionary history of mammalian gene expression.Genome research · 2019Article
- The ancestral levels of transcription and the evolution of sexual phenotypes in filamentous fungi.PLoS genetics · 2017Article
- Chromatin remodelers: We are the drivers!!Nucleus (Austin, Tex.) · 2016Review
- Drosophila melanogaster Zelda and Single-minded collaborate to regulate an evolutionarily dynamic CNS midline cell enhancer.Developmental biology · 2012Article
- From L-dopa to dihydroxyphenylacetaldehyde: a toxic biochemical pathway plays a vital physiological function in insects.PloS one · 2011Article
- The LTR retrotransposon micropia in the cardini group of Drosophila (Diptera: Drosophilidae): a possible case of horizontal transfer.Genetica · 2008Article
- Quantitative trait loci responsible for variation in sexually dimorphic traits in Drosophila melanogaster.Genetics · 2003Article
- Evolutionary novelties in islands: Drosophila santomea, a new melanogaster sister species from São Tomé.Proceedings. Biological sciences · 2000Article
- Discovery of a novel, paternally expressed ubiquitin-specific processing protease gene through comparative analysis of an imprinted region of mouse chromosome 7 and human chromosome 19q13.4.Genome research · 2000Article
- Decoupled evolution of coding region and mRNA expression patterns after gene duplication: implications for the neutralist-selectionist debate.Proceedings of the National Academy of Sciences of the United States of America · 2000Article
- The correlation between synonymous and nonsynonymous substitutions in Drosophila: mutation, selection or relaxed constraints?Genetics · 1998Article
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
Abstract
The hypothesis that morphological evolution may largely result from changes in gene regulation rather than gene structure has been difficult to test. Morphological differences among insects are often apparent in the cuticle structures produced. The dopa decarboxylase (Ddc) and alpha-methyldopa hypersensitive (amd) genes arose from an ancient gene duplication. In Drosophila, they have evolved nonoverlapping functions, including the production of distinct types of cuticle, and for Ddc, the production of the neurotransmitters, dopamine and serotonin. The amd gene is particularly active in the production of specialized flexible cuticles in the developing embryo. We have compared the pattern of amd expression in three Drosophila species. Several regions of expression conserved in all three species but, surprisingly, a unique domain of expression is found in Drosophila simulans that does occur in the closely related (2-5 million years) Drosophila melanogaster or in the more remote (40-50 million years) Drosophila virilis. The "sudden" appearance of a completely new and robust domain of expression provides a glimpse of evolutionary variation resulting from changes in regulation of structural gene expression.
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