ArticleProceedings of the National Academy of Sciences of the United States of America1996
High mobility group I(Y)-like DNA-binding domains on a bacterial transcription factor.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
18 citing papers in PubMed, 55 citations in OpenAlex.
- Structural basis of transcriptional activation by the Mycobacterium tuberculosis intrinsic antibiotic-resistance transcription factor WhiB7.Molecular cell · 2021Article
- Light-Triggered Carotenogenesis inMicroorganisms · 2021Review
- LtpA, a CdnL-type CarD regulator, is important for the enzootic cycle of the Lyme disease pathogen.Emerging microbes & infections · 2018Article
- Evolutionary convergence and divergence in archaeal chromosomal proteins and Chromo-like domains from bacteria and eukaryotes.Scientific reports · 2018Article
- Article
- Structural insights into RNA polymerase recognition and essential function of Myxococcus xanthus CdnL.PloS one · 2014Article
- WhiB7, an Fe-S-dependent transcription factor that activates species-specific repertoires of drug resistance determinants in actinobacteria.The Journal of biological chemistry · 2013Article
- Structure of the Mtb CarD/RNAP β-lobes complex reveals the molecular basis of interaction and presents a distinct DNA-binding domain for Mtb CarD.Structure (London, England : 1993) · 2013Article
- High-mobility-group a-like CarD binds to a DNA site optimized for affinity and position and to RNA polymerase to regulate a light-inducible promoter in Myxococcus xanthus.Journal of bacteriology · 2013Article
- CdnL, a member of the large CarD-like family of bacterial proteins, is vital for Myxococcus xanthus and differs functionally from the global transcriptional regulator CarD.Nucleic acids research · 2010Article
- Functional equivalence of HMGA- and histone H1-like domains in a bacterial transcriptional factor.Proceedings of the National Academy of Sciences of the United States of America · 2009Article
- Differential expression of a putative CarD-like transcriptional regulator, LtpA, in Borrelia burgdorferi.Infection and immunity · 2008Article
- Genetic dissection of the light-inducible carQRS promoter region of Myxococcus xanthus.Journal of bacteriology · 2004Article
- Article
- The Stigmatella aurantiaca homolog of Myxococcus xanthus high-mobility-group A-type transcription factor CarD: insights into the functional modules of CarD and their distribution in bacteria.Journal of bacteriology · 2003Article
- ihfA gene of the bacterium Myxococcus xanthus and its role in activation of carotenoid genes by blue light.Journal of bacteriology · 2001Article
- Comparative genome analysis of the pathogenic spirochetes Borrelia burgdorferi and Treponema pallidum.Infection and immunity · 2000Article
- Intra- and intermolecular cooperative binding of high-mobility-group protein I(Y) to the beta-interferon promoter.Molecular and cellular biology · 1997Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
5 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
The bacterium Myxococcus xanthus responds to blue light by producing carotenoids. It also responds to starvation conditions by developing fruiting bodies, where the cells differentiate into myxospores. Each response entails the transcriptional activation of a separate set of genes. However, a single gene, carD, is required for the activation of both light- and starvation-inducible genes. Gene carD has now been sequenced. Its predicted amino acid sequence includes four repeats of a DNA-binding domain present in mammalian high mobility group I(Y) proteins and other nuclear proteins from animals and plants. Other peptide stretches on CarD also resemble functional domains typical of eukaryotic transcription factors, including a very acidic region and a leucine zipper. High mobility group yI(Y) proteins are known to bind the minor groove of A+T-rich DNA. CarD binds in vitro an A+T-rich element that is required for the proper operation of a carD-dependent promoter in vivo.
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.