ArticleProceedings of the National Academy of Sciences of the United States of America1996
Surface antigen cross-linking triggers forced exit of a protozoan parasite from its host.
Article in Proceedings of the National Academy of Sciences of the United States of America, 1996. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 14 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
14 citing papers in PubMed, 62 citations in OpenAlex.
- Antibodies to variable surface antigens induce antigenic variation in the intestinal parasite Giardia lamblia.Nature communications · 2023Article
- Acute immune responses in zebrafish and evasive behavior of a parasite - who is winning?Frontiers in cellular and infection microbiology · 2023Article
- Protection of Grouper AgainstFrontiers in immunology · 2022Article
- Immune response to Ichthyophthirius multifiliis and role of IgT.Parasite immunology · 2020Review
- Passive Immunization Delays Disease Outcome in Gilthead Sea Bream Infected WithFrontiers in immunology · 2020Article
- Convergent Evolution of Mucosal Immune Responses at the Buccal Cavity of Teleost Fish.iScience · 2019Article
- Characterization and immune regulation role of an immobilization antigen from Cryptocaryon irritans on groupers.Scientific reports · 2019Article
- Mucosal immunoglobulins protect the olfactory organ of teleost fish against parasitic infection.PLoS pathogens · 2018Article
- Vertebrate Adaptive Immunity-Comparative Insights from a Teleost Model.Frontiers in immunology · 2017Review
- New cell motility model observed in parasitic cnidarian Sphaerospora molnari (Myxozoa:Myxosporea) blood stages in fish.Scientific reports · 2016Article
- Article
- Systemic and cutaneous mucus antibody responses of channel catfish immunized against the protozoan parasite Ichthyophthirius multifiliis.Clinical and diagnostic laboratory immunology · 2003Article
- Surface immobilization antigen of the parasitic ciliate Ichthyophthirius multifiliis elicits protective immunity in channel catfish (Ictalurus punctatus).Clinical and diagnostic laboratory immunology · 2002Article
- Passive immunization of channel catfish (Ictalurus punctatus) against the ciliated protozoan parasite Ichthyophthirius multifiliis by use of murine monoclonal antibodies.Infection and immunity · 1996Article
Corrections and comments
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Authors and funding
3 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
We used the common fish pathogen Ichthyophthirius multifiliis as a model for studying interactions between parasitic ciliates and their vertebrate hosts. Although highly pathogenic, Ichthyophthirius can elicit a strong protective immune response in fish after exposure to controlled infections. To investigate the mechanisms underlying host resistance, a series of passive immunization experiments were carried out using mouse monoclonal antibodies against a class of surface membrane proteins, known as immobilization antigens (or i-antigens), thought to play a role in the protective response. Such antibodies bind to cilia and immobilize I. multifiliis in vitro. Surprisingly, we found that passive antibody transfer in vivo caused rapid exit of parasites from the host. The effect was highly specific for a given I. multifiliis serotype. F(ab)2 subfragments had the same effect as intact antibody, whereas monovalent Fab fragments failed to protect. The activity of Fab could, nevertheless, be restored after subsequent i.p. injection of bivalent goat anti-mouse IgG. Parasites that exit the host had detectable antibody on their surface and appeared viable in all respects. These findings represent a novel instance among protists in which protective immunity (and evasion of the host response) result from an effect of antibody on parasite behavior.
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